We reported the antimicrobial activities of cobalt and nickel complexes containing imino-NHC ligands. Complex 2 was synthesized by direct reaction of the insitu generated free carbene from 2-[2-(3-benzylimidazol-1-yl)ethyliminomethyl]phenol ligand with NiCl2 diglyme while complexes 3-5 were previously reported as catalysts in the transfer hydrogenation reaction of ketones. The compounds 1-5 were screened for antimicrobial sensitivity test against four gram-negative bacteria Escherichia Coli (E-coli), Shigella, Klebsiella Pneumoniae (K. Pneumoniae) and Salmonella Typhi (S.Typhi) and a gram positive bacteria Staphylocossus aureus (S.aureus). At a varying concentrations of 100, 200, 300, 400 and 500 µg/mL, significant activities were recorded using disc diffusion methods. The cobalt complex 3 was found to have higher activities compared with the corresponding nickel complexes and among the three nickel complexes, nickel complex with pyridine as wingtip was found to be more active than the one with a benzyl group. Similarly, the nickel centre with mononuclear was found to be more active than the tri-nuclear nickel complex. Except for the cobalt complex 3 no activity was recorded against S. typhi for all the nickel compounds.
Green synthesis of ZnO@SiO2 nanocomposite was performed using Gum Arabic. The green synthesized nanocomposite was characterized using Fourier Transform Infrared Spectrophotometer (FTIR), The Scanning Electron Microscopy (SEM), UV-Visible spectrophotometer, Dynamic Light Scattering (DLS), and X-Ray Fluorescence (XRF). The toxicity study was conducted for 24 hours on 1st to 4th larval instars of malaria vectors at various concentrations (10, 20 and 25 mg/L). The LC50 and LC90 for the 1st - 4th larval instars were found to be in the range of 9.11 - 18.288 mg/L and 157.254 - 126.132 mg/L respectively. A strong positive correlation between concentrations of the nanocomposite and mortality of larval instars (0.945 - 0.997). These values indicate that the mortality rates increased with an increase in concentrations. ZnO@SiO2 nanocomposite is a potential nano-larvicide for malaria vector control in tropical countries with high malaria incidence.
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