Objective: To identify the inhibitory effects of artemisinin and its derivatives against Alpha-Amylase in DiabetesII.Study Design: Insilico approaches using Bioinformatics techniques were used to access the effects of arteisininand its derivatives.Place and Duration of Study: The study was conducted comprising 6 month period at Capital University ofScience and Technology, Islamabad, Pakistan.Materials and Methods: In this work, the inhibitory effects of artemisinin and its derivatives were determinedby using in silico approach. For proper inhibitory effects, molecular docking and the pharmacokineticproperties of the ligand were identified.Results: Artemether was found to be the ligand that shows the best binding energy -7.08 Kcal/mol, stronghydrogen bonding, 4 alkyl bonds, 0 bumps, inhibition constant 13.26, and better pharmacokinetic properties. Ithas been selected as a lead compound as it is the most active compound for alpha-amylase inhibition.Conclusion: In future, this work can be used in wet-lab analysis to confirm its adequacy and efficacy.
Objective: To assess and compare the Knowledge, Attitude, and Practices of Medical and Nursing Students regarding Basic Life Support Training Methodology: This cross-sectional study was done at the Shalamar Institute of Health Sciences, Lahore in a period of three months. Students from all years of MBBS and BS Nursing were taken as subjects. Participants satisfying inclusion criteria were requested to fill out a self-structured pre-tested questionnaire after informed consent. Data was analyzed using SPSS v.21. Results: There were 330 participants from MBBS and BS Nursing (50 from each class of MBBS and 20 from each class of BS Nursing). The age of participants ranged from 18 to 30 (Figure 1). Only 250 subjects had heard about BLS. Out of 330 participants, only 204 had good knowledge about BLS (Table 2) and 126 had poor knowledge of BLS where score of higher than 3 out of 7 was considered as good. Knowledge of Medical and Nursing students was compared and the p-value came out to be 0.088, which was considered insignificant. Only 34.5% of the participants had learned BLS by training and only 13.3% of the participants (Table 3) had practically done BLS. Most of the people gave no reason for not attending a training session for BLS. Conclusion: It was concluded that medical and nursing students had satisfactory knowledge of BLS and more attention was needed towards this important life-saving skill.
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