15auch durch Dehnung derselben entstandenen grofle Aehnlichkeit haben, findet man vielfach bei den in der Natur vorkommenden organischen und anorganisehen Bildungen vertreten. Am typischsten vertreten ist diese Struktur bei Liingsschnitten dutch verholzte Membrane, wie man sie auf gehobelten Holzplatte~ sehr seh6n beobachten kann. W i s I i c e n u s 6) hat eine Theorie der Verholzung bei den pflanzlichen Faserstoffen auf kolloidchemischer Grundlage aufgestellt, und lii6t sich eine gewisse Aehnlichkeit bei diesen Vorgiingen mit den rhythmischen Erscheinungen in Gallerten nicht abstreiten. Auch bei dem Verholzungsproze6 wird man demnaeh die Abund Einlagerung der ausgeschiedenen Substanzen in Form kolloider Partikelchen in abwechselnd diehten und weiten Schichten verfolgen k6nnen.Bei diesen Diffusionsvofg~ingen ist es zur Erzeugung der Strukturen vollkommen gleiehgiltig, ob eine der reagierenden Verbindungen in den gallertartigen Substanzen bereits vorher ') Wislicenus, Koll.-Zeitscht. '6, 17 (1910

No abstract

Carbamazepine has been shown to induce several P450 cytochromes including CYP3A4 and CYP1A2. Since CYP1A2 plays a role in the metabolic clearance of olanzapine, the interaction may be attributed to induction of CYP1A2 by carbamazepine, leading to increased first-pass and systemic metabolism of olanzapine. The interaction is not considered to be of clinical significance because olanzapine has a wide therapeutic index, and the changes in plasma concentration of olanzapine are within the fourfold variation that occurs without concern for safety in a patient population.

The majority of paediatric oncology units in Australia and New Zealand provide dedicated multidisciplinary bereavement support services. There is variation in services provided, often due to a lack of resources and staffing. Findings indicate a need to further develop bereavement programmes, improve staff education and support, and increase the availability of resources in this area. Future research should explore the needs of bereaved families, as well as the range of services and evaluation methods that could be implemented as the baseline for 'best practice' hospital-based bereavement programmes.

While dysphoria is a well-recognized reaction in healthy volunteers, it is probably insufficiently recognised in patients, particularly if it occurs in the absence of akathisia. Better detection could improve compliance in patients.

Summary:Purpose: Talampanel (LY300164), a potent and selective ␣-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-receptor antagonist, is a potential new antiepileptic drug (AED). This study examines the single-and multiple-dose pharmacokinetics, safety, and tolerability of talampanel in patients with intractable epilepsy and assesses the potential for pharmacokinetic interaction.Methods: Eleven of 14 patients entered into the study completed. Fourteen patients were evaluated for safety, 13 patients were used in the single-dose, and 11 patients in the multipledose pharmacokinetic analysis. Each patient initially received a single 35-mg dose of talampanel followed by the measurement of pharmacokinetic profiles. A 21-day t.i.d. dosing regimen was then determined for each patient based on his or her initial pharmacokinetic profile. Adverse events were recorded by patients or their carers.Results: After oral ingestion, talampanel was rapidly absorbed, with maximal plasma concentrations achieved within 1-3 h. Talampanel concentrations in patients taking enzymeinducing AEDs were 50% lower than those seen in healthy volunteers. Mean talampanel t 1 /2 values were 3.0 h compared with 4.2 h in healthy volunteers. After multiple-dose and steady-state, talampanel t 1 /2 values were increased to 5.6 h Talampanel and valproic acid (VPA) appear to inhibit each other's metabolism mutually. Talampanel had no effect on plasma concentrations of other AEDs. Multiple-dose talampanel administration was associated with nonlinear pharmacokinetics. No serious adverse events were reported; the most frequently reported being dizziness, ataxia, drowsiness, and headachesConclusions: Talampanel dosing strategies may be reliant on concomitant AED medication, as enzyme-inducing AEDs enhance, whereas VPA inhibits its metabolism. Talampanel was well tolerated, although adverse events occurred at lower doses compared with those in healthy subjects, probably because of the additive effect of concomitant AEDs.

No abstract

Binding of [123I]ADAM to SERT in midbrain can be quantified with a single scan starting 200 min after injection. However, the variability of estimated occupancy values may be too high for critical assessment of occupancy of SERT by SSRI.