No abstract

Paper describing numerous treatments for and theories on the cause of parturient paresis 4 1955 Prevention of parturient paresis by administration of vitamin orally^^^^ 1961 First report of the existence of a hypocalcemic agent from (23) the parathyroid-thyroid complex 1963 Discovery of an active hypocalcemic agent, thyrocalcitonin, in extracts of the thyroid glands 1963 Development of a radioimmunoassay for plasma parathormone concentration in the cow^^^ Characterization of Parturient Paresis Normal plasma calcium concentrations of the dairy cow range approx imately from 8.5 to 11.4 mg per 100 ml.^ As calcium concentration falls, the muzzle become dry; the ears become cold; body temperature is first elevated, then declines; and the animal becomes hyperexcitable and.later 86 mentally depressed. The first signs of unsteadiness and incoordination are observed-when plasma calcium falls below about 7.5 mg per 100 ml. Staggering, muscle twitching in the rear flanks and falling into a recum bent position with an inability to rise occur when total calcium drops below 5 mg per 100 ml. Labored breathing, lateral recumbency and some bloating are present ;dien calcium falls below 4 mg per 100 ml of plasma. 73 Coma and death usually follow. Other changes in blood concentrations are associated with the devel-20 42, 79 opment of hypocalcemia. Inorganic phosphorus levels fall ' from a normal plasma concentration ranging from 3.1 to 6.0 mg per 100 ml.^ Hypermagnesemia from a normal range of 1.8 to 3.2 mg per 100 ml of plasma occurs^' as does hyperglycemia. Sherwood et and Mayer et exceed 50 g per day. The initiation of lactation is the precipitating

Paper describing numerous treatments for and theories on the cause of parturient paresis 4 1955 Prevention of parturient paresis by administration of vitamin orally^^^^ 1961 First report of the existence of a hypocalcemic agent from (23) the parathyroid-thyroid complex 1963 Discovery of an active hypocalcemic agent, thyrocalcitonin, in extracts of the thyroid glands 1963 Development of a radioimmunoassay for plasma parathormone concentration in the cow^^^ Characterization of Parturient Paresis Normal plasma calcium concentrations of the dairy cow range approx imately from 8.5 to 11.4 mg per 100 ml.^ As calcium concentration falls, the muzzle become dry; the ears become cold; body temperature is first elevated, then declines; and the animal becomes hyperexcitable and.later 86 mentally depressed. The first signs of unsteadiness and incoordination are observed-when plasma calcium falls below about 7.5 mg per 100 ml. Staggering, muscle twitching in the rear flanks and falling into a recum bent position with an inability to rise occur when total calcium drops below 5 mg per 100 ml. Labored breathing, lateral recumbency and some bloating are present ;dien calcium falls below 4 mg per 100 ml of plasma. 73 Coma and death usually follow. Other changes in blood concentrations are associated with the devel-20 42, 79 opment of hypocalcemia. Inorganic phosphorus levels fall ' from a normal plasma concentration ranging from 3.1 to 6.0 mg per 100 ml.^ Hypermagnesemia from a normal range of 1.8 to 3.2 mg per 100 ml of plasma occurs^' as does hyperglycemia. Sherwood et and Mayer et exceed 50 g per day. The initiation of lactation is the precipitating