plex regional pain syndromes involving one major peripheral nerve suggests that neuroaugmentation may be applicable to the peripheral occipital nerves. Occipital neuralgia is characterized by paroxysms ofWe report a new application of peripheral electropain occurring within the distribution of the greater stimulation for the treatment of medically intractaand/or lesser occipital nerves (1). The pain may ble occipital neuralgia. radiate anteriorly to the ipsilateral frontal or retroReprint requests to Richard L. Weiner, MD, Dallas Neurosurgical Associates, 8230 Walnut Hill Lane, Suite 220, Dallas, TX 75231.
This prospective, multicenter study confirms that spinal cord stimulation can be an effective therapy for management of chronic low back and extremity pain. Significant improvements in many aspects of the pain condition were measured, and complications were minimal.
In this study we used a dominant‐negative FGF receptor mutant to block FGF function in a specific tissue of transgenic mice. The mutant receptor, which is known to block signal transduction in cells when co‐expressed with wild‐type receptors, was targeted to suprabasal keratinocytes using a keratin 10 promoter. The transgene was expressed specifically in the skin and highest expression levels were found in the tail. Expression of the mutant receptor disrupted the organization of epidermal keratinocytes, induced epidermal hyperthickening and resulted in an aberrant expression of keratin 6. This suggests that FGF is essential for the morphogenesis of suprabasal keratinocytes and for the establishment of the normal program of keratinocyte differentiation. Our study demonstrates that dominant‐negative growth factor receptors can be used to block selectively the action of a growth factor in specific tissues of transgenic mice.
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