We present a homogeneous catalog of 275 large (effective radius 5.3 ) ultra-diffuse galaxy (UDG) candidates lying within an ≈ 290 square degree region surrounding the Coma cluster. The catalog results from our automated postprocessing of data from the Legacy Surveys, a three-band imaging survey covering 14,000 square degrees of the extragalactic sky. We describe a pipeline that identifies UDGs and provides their basic parameters. The survey is as complete in these large UDGs as previously published UDG surveys of the central region of the Coma cluster. We conclude that the majority of our detections are at roughly the distance of the Coma cluster, implying effective radii ≥ 2.5 kpc, and that our sample contains a significant number of analogs of DF 44, where the effective radius exceeds 4 kpc, both within the cluster and in the surrounding field. The g − z color of our UDGs spans a large range, suggesting that even large UDGs may reflect a range of formation histories. A majority of the UDGs are consistent with being lower stellar mass analogs of red sequence galaxies, but we find both red and blue UDG candidates in the vicinity of the Coma cluster and a relative overabundance of blue UDG candidates in the lower density environments and the field. Our eventual processing of the full Legacy Surveys data will produce the largest, most homogeneous sample of large UDGs.

We present spectra of five ultra-diffuse galaxies (UDGs) in the vicinity of the Coma cluster obtained with the Multi-object Double Spectrograph on the Large Binocular Telescope. We confirm four of these as members of the cluster, quintupling the number of spectroscopically confirmed systems. Like the previously confirmed large (projected half-light radius >4.6 kpc) UDG, DF44, the systems we targeted all have projected half-light radii 2.9 kpc > . As such, we spectroscopically confirm a population of physically large UDGs in the Coma cluster. The remaining UDG is located in the field, about 45 Mpc behind the cluster. We observe Balmer and Ca II H and K absorption lines in all of our UDG spectra. By comparing the stacked UDG spectrum against stellar population synthesis models, we conclude that, on average, these UDGs are composed of metal-poor stars ([Fe/H]−1.5). We also discover the first UDG with [O II] and [O III] emission lines within a clustered environment, demonstrating that not all cluster UDGs are devoid of gas and sources of ionizing radiation.

No abstract

Doxorubicin is an effective anticancer chemotherapeutic agent known to cause acute and chronic cardiomyopathy. To develop a more sensitive echocardiographic screening test for cardiac damage due to doxorubicin, a cohort study was performed using dobutamine infusion to differentiate asymptomatic long-term survivors of childhood cancer treated with doxorubicin from healthy control subjects. Echocardiographic data from the experimental group of 21 patients (mean age 16 +/- 5 years) treated from 1.6 to 14.3 years (median 5.3) before this study with 27 to 532 mg/m2 of doxorubicin (mean 196) were compared with echocardiographic data from 12 normal age-matched control subjects. Graded dobutamine infusions of 0.5, 2.5, 5 and 10 micrograms/kg per min were administered. Echocardiographic Doppler studies were performed before infusion and after 15 min of infusion at each rate. Dobutamine infusion at 10 micrograms/kg per min was discontinued after six studies secondary to a 50% incidence rate of adverse symptoms. The most important findings were that compared with values in control subjects, end-systolic left ventricular posterior wall dimension and percent of left ventricular posterior wall thickening in doxorubicin-treated patients were decreased at baseline study and these findings were more clearly delineated with dobutamine stimulation. End-systolic left ventricular posterior wall dimension at baseline for the doxorubicin-treated group was 11 +/- 1.9 mm versus 13.1 +/- 1.5 mm for control subjects (p less than 0.01). End-systolic left ventricular posterior wall dimension at the 5-micrograms/kg per min dobutamine infusion for the doxorubicin-treated group was 14.1 +/- 2.4 mm versus 19.3 +/- 2.6 mm for control subjects (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Thirteen fetuses with nonimmune hydrops (22 to 39 weeks of gestation) were evaluated with two-dimensional and M-mode echocardiography. Ten fetuses had cardiovascular abnormalities resulting in heart failure, and three had noncardiac causes of hydrops. In three cases, hydrops was caused by supraventricular tachycardia. One of these fetuses responded to cardioversion at birth, another responded to transplacental digoxin therapy, and the third died with atrial flutter and high-grade atrioventricular block before delivery. There were no cases of "idiopathic" hydrops. Our results show that fetal echocardiography is useful in determining cardiac causes of in utero heart failure resulting in hydrops fetalis. The fetal echocardiogram may also be used in monitoring transplacental therapy of heart failure.