Richard J. Franklin scite author profile

Background: Sclerostin, an inhibitor of Wnt signaling, binds to the ␤-propeller domain-containing Wnt co-receptors LRP6 and LRP4. Results: An NXI motif in sclerostin mediates interactions with LRP6 (but not LRP4) and blocks Wnt1 signaling. Conclusion:The sclerostin/LRP6 interaction shares features with the well characterized nidogen/laminin interaction. Significance: NXI motifs are important in mediating interactions with ␤-propeller containing proteins.

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Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase

Porter

Lumb

Lecomte

et al. 2009

Bioorganic & Medicinal Chemistry Letters

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Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

Porter

Lumb

Franklin

et al. 2009

Bioorganic & Medicinal Chemistry Letters

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Studies on the oxidation of 1, 3-dithiane and 5, 5-disubstituted analogues including X-ray crystal structure, equilibration studies and pK a measurements on selected oxides

Aggarwal¹,

Davies²,

Franklin³

et al. 1994

J. Chem. Soc., Perkin Trans. 1

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Synthesis, X-ray crystal structure, equilibration studies and anion chemistry of trans-1,3-dithiane 1,3-dioxide

Aggarwal¹,

Davies²,

Franklin³

et al. 1991

J. Chem. Soc., Perkin Trans. 1

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