RECEIVED AUGCST 30, 1934 Conductances, densities and viscosities of solutions of lithium chloride and of potassium and sodium chlorides, bromides and iodides in N-methylacetamide have been measured within the temperature range from 30 to 60" for concentrations which ranged from 5 X 10-4 to 1.0 or 2.0 molar. Kohlrausch plots for all of the systems exhibit relatively good agreement with the Onsager limiting equation to concentrations of 0.01 molar or more. Plots of the product of the equivalent conductance and the square root of the relative viscosity of the solution versus the square root of the concentration yield straight lines to 0.3 molar or above. The Kohlrausch law of independent ion mobilities is shown to be valid in these solutions.

A 48-yr-old man with squamous cell carcinoma of the lung, hypercalcemia, and brain metastases with seizures was treated with phenytoin. Constant nasogastric infusion with Osmolyte was begun for hydration and nutritional status, necessitating an increase in his phenytoin dosage. Adequate seizure control and phenytoin levels were obtained on this adjusted regimen. However, on the 16th hospital day, the patient pulled out his nasogastric tube and received two doses of phenytoin without Osmolyte. The patient became lethargic, and his phenytoin level was 53 micrograms/ml. The patient was placed on bolus nasogastric feedings and a lower dose of phenytoin administered between feedings. Adequate seizure control and appropriate phenytoin levels were obtained with no further problems. The recommended management of the phenytoin-enteral feeding interaction is to flush and clamp the nasogastric tube for 2 hr before and 2 hr after the phenytoin dose.

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