A series of 26 hypercellular periductal stromal tumors of the breast, commonly referred to as cystosarcoma phyllodes, is reported. Twelve neoplasms were classified histologically as benign and 14 (54%) as maligant after microscopic assessment of the stromal elements. None of the histologically benign cystosarcomas metastasized, although two recurred locally. Malignant transformation was not observed in the recurrent tumors. Local recurrences developed in four women with histologically malignant cystosarcomas and caused the death of one by direct extension into the lung. Pulmonary metastases of the sarcomatous element occurred in three. Two of these women died and one has survived 16 years after pulmonary lobectomy. Separation of cystosarcomas into benign and malignant categories on the basis of their histopathologic features is advocated. It is likely that overgrowth of the sarcomatous stroma is a prerequisite for metastasis.
The relative importance of convection by secondary flows and diffusion by turbulence as mechanisms responsible for mixing in multistage, axial-flow compressors has been investigated by using the ethylene tracer-gas technique and hot-wire anemometry. The tests were conducted at two loading levels in a large, low-speed, four-stage compressor. The experimental results show that considerable cross-passage and spanwise fluid motion can occur and that both secondary flow and turbulent diffusion can play important roles in the mixing process, depending upon location in the compressor and loading level. In the so-called freestream region, turbulent diffusion appeared to be the dominant mixing mechanism. However, near the endwalls and along airfoil surfaces at both loading levels, the convective effects from secondary flow were of the same order of magnitude as, and in some cases greater than, the diffusive effects from turbulence. Calculations of the secondary flowfield and mixing coefficients support the experimental findings.
The concentrations of intracellular elements were determined by electron microprobe analysis in the nucleus and cytoplasm of freeze-dried cryosections of superficial proximal and distal tubules of the rat kidney. For the nucleus of the proximal tubular cell, the concentrations of sodium and chloride were 20 and 23 mmoles/kg of wet wt, and those of potassium and phosphorus were 144 and 150 mmoles/kg wet wt. For the nucleus of the distal tubular cell, the concentrations of sodium and chloride were significanlty lower (11 and 13 mmoles/kg wet wt), that of potassium was unchanged (143 mmoles), and that of phosphorus was significantly higher (175 mmoles). Towards the basolateral infoldings of the proximal and distal tubules and the brush border of the proximal tubules, the concentrations of sodium and chloride were higher and those of potassium and phosphorus were lower than those obtained in the nucleus, indicating the presence of extracellular compartments in these regions. Measurements performed in the centrally located cytoplasm of proximal and distal tubular cells, close to the nucleus, showed sodium and potassium concentrations to the indistinguishable from those in the nucleus, whereas chloride and phosphorus concentrations were considerably higher. These data demonstrate differences in the intracellular concentrations of phosphorus, sodium, and chloride between proximal and distal tubular cells. In neither the proximal nor the distal tubular cells, however, could a concentration difference for sodium and potassium between nucleus and cytoplasm be determined.
The synthesis of a new, all-phosphorus pincer PP(NEt2)P ligand L3(NEt2), which is derived from 2-indolylphosphine and features a central N(2)P(NEt(2)) core, is described. This 'PPP' species shows coordination toward Rh as a neutral trisphosphine ligand. Tridentate diphenylphosphine-derived PP(H)P ligands L1(H) and L2(H), featuring a secondary phosphine core, show 'ambivalent' coordination, acting as persistent neutral triphosphine ligands with Rh, and as easily-formed monoanionic phosphido(bisphosphine) pincer ligands toward Pd. These subtle differences, which might be more general for group 9 and 10 metal complexes with this ligand set, are explained by comparative DFT calculations (BP86; def2-TZVP level of theory) for the Rh and Pd species involved, including those with the structurally related PN(H)P ligands. The optimized structure for complex PdCl(L2) indicates minimal overlap of available Pd d-orbitals with the lone pair of the central, deprotonated phosphorus atom (formally a phosphido fragment), suggesting that it behaves predominantly like a bulky phosphine instead of a phosphido fragment.
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