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A 3-D porous apatite scaffold (B-HA), recently obtained through biomorphic transformation of a natural wood, is investigated on its multi-scale porous structure determining superior mechanical properties and biological behaviour. B-HA shows hierarchical pore architecture with wide aligned channels interconnected with smaller tubules, thus recapitulating in detail the lymphatic network of the original wood template. As induced by its biomimetic architecture, B-HA displays values of compression and tensile strength and stiffness, higher than the values usually measured in sintered ceramics with isotropic porosity. Furthermore, B-HA shows a ductility not common for a pure ceramic body and a tensile strength higher than its compression strength, thus occupying a zone in the Ashby chart where ceramics are usually not present. Cell co-culture tests in bioreactor report encouraging results in enhancing the complex tissue regeneration process, thus making B-HA very promising as a scaffold able to promote bone regeneration, particularly for large bone defects.

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