A child with colonic Hirschsprung disease is presented who required permanent parenteral feeding. Septical and thrombotic complications in the central catheters including pulmonary thromboembolism were observed. Diagnosis with Doppler ultrasound and ventilation perfusion scan allowed early therapy and adequate follow-up.
Twenty two children with congenital hypothyroidism (CHT) were studied in order to evaluate the occurrence of neurologic damage. Their disease was recognized on clinical grounds and subsequently confirmed by laboratory tests and diagnosis was dones usually late, most frecuently after several years, thus 95% of our cases had neurologic disturbances of variable severity, 91%had sub-normal IQ and 59%required special education. (Key words: Hypothyroidism, congenital, age at diagnosis, mental subnormality).La incidencia del hipotiroidismo congenito (HTC) es de 1 por 3.000 a 1 por 6.000 recien nacidos (RN) vivos 1 -2 * 3 ' 4 . La etiologfa mas frecuente corresponde a trastornos en el desarrollo de la glandula tiroides, siendo el defecto en la hormonogenesis mucho mas raro. El hipotiroidismo de origen hipotalamo-hipofisdario, aquel por resistencia periferica a hormonas tiro ideas, por ingestion de drogas antitirofdeas durante el embarazo y el cretinismo endemico, son excepcionales.Las manifestaciones clinicas en el RN son variables, el cuadro puede presentarse como un sindrome de hipotiroidismo franco con o sin bocio, o ser totalmente asintomatico. En estos casos el diagnostico es formulado por determinaciones hormonales sistematicas.Las secuelas neurologicas y el retardo mental constituyen el problema mas relevante del HTC no tratado o tratado tardiamente 5 -6 ' 6 -8 . En el presente estudio se evaluan estas secuelas en pacientes hipotirofdeos, que al momento del diagnostico presentaron manifestaciones clmicas de hipotiroidismo.
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