Diminazene aceturate (DA) is the active component of some trypanocidal drugs used for the treatment of animals infected with trypanosomosis and babesiosis. Residues of DA may cause hepatotoxic and nephrotoxic effects. Therefore, the purpose of this study was to investigate the occurrence of oxidative stress, i.e., changes in the antioxidant defense system of rats treated with a single dose of 3.5 mg kg(-1) of DA. All treatments were intramuscularly administered, and evaluations were performed on days 7 and 21 post-treatment (PT). Liver and kidney samples were collected and evaluated by histopathology and oxidative stress parameters (thiobarbituric acid-reactive species, catalase, superoxide dismutase, carbonyl, non-protein thiols, and reduced glutathione). Finally, blood was collected to determine seric DA concentration. Superoxide dismutase (SOD) and catalase (CAT) activities in liver and kidney of rats were dramatically inhibited (p < 0.05) compared to the control group on day 21 PT. This difference is related to the concomitant increase (p < 0.05) in malondialdehyde (MDA) content, which was identified by an increase in thiobarbituric acid-reactive species (TBARS) levels. The carbonyl levels did not differ between groups (p > 0.05). Both non-protein thiols (NPSH) and glutathione (GSH) levels in liver and kidney decreased (p < 0.05) on day 21 PT. Chromatographic analyses showed lower levels of DA on day 21 PT compared to day 7 PT. A negative correlation was observed between DA concentration in serum and lipid peroxidation in liver and kidney tissues on 21 days PT. Histopathology revealed vacuolar degeneration in liver and kidney samples on day 21 PT. Our findings indicate that DA could cause oxidative damage to liver and kidney of rats.
Liquid pig manure (LPM) is widely used as a compost fertilizer for vegetable crops destined for human consumption. However, these wastes may contain parasites eggs, such as the nematode Ascaris suum, that pose serious health risks to humans. We attempted to determine the most appropriate technique for recovering A. suum eggs from LPM compost. Samples were collected from two waste sources during composting, including 23 samples containing LPM, sawdust, and wood shavings, and 14 samples of LPM alone-both in triplicate. Samples were analyzed using several different recovery methods. Recovery of eggs by the modified Bailenger method with adaptations was significantly more effective and recovered 57% more eggs than by the modified Bailenger method alone. Willis-Mollay method, modified Faust method, and the simple sedimentation technique only recovered 4.4%, 13.9%, and 26% of eggs, respectively, compared with the modified Bailenger method with adaptations, indicating that the adjustments made to the Bailenger method were key to improving the recovery of A. suum eggs from compost and LPM.
RESUMOEste estudo tem como objetivo relatar a experiência de um grupo de estudantes da área da saúde, durante um projeto de promoção de saúde na escola, em especial as atividades de Brazilian Journal of health ReviewBraz. J. Hea. Rev., Curitiba, v. 3, n. 1, p.991-1001 jan./feb. 2020. ISSN 2595-6825 992 educação em saúde bucal. As atividades foram organizadas e realizadas por estudantes dos cursos de Odontologia, Enfermagem e do Mestrado em Ciência da Saúde e da Vida da Universidade Franciscana (UFN), Santa Maria-RS. O propósito das atividades foi de fortalecer a colaboração intersetorial da área da saúde com a escola. Para isso, foram utilizadas ferramentas lúdicas, atividades que promoveram conhecimento e discussão para solucionar dúvidas. E, também, a realização de uma escovação supervisionada, com a equipe interdisciplinar auxiliando e orientando os alunos. A atuação interdisciplinar permitiu a abrangência de conhecimentos e a integração da equipe, além de levar informação e motivação em saúde bucal para as crianças. Palavras-chave: Higiene bucal. Odontologia. Práticas interdisciplinares. ABSTRACTThis study aims to report on the experience of a group of health students, during a during a health promotion project at in the school, especially oral health education activities. The activities were organized and conducted by students of Dentistry, Nursing and the Masters Sciences of the Health and Life of the Franciscan University (UFN), Santa Maria-RS. The purpose of the activities was to strengthen the intersectoral collaboration of the health area with the school. For this, playful tools were used, activities that promoted knowledge and discussion to solve doubts. And, also, the accomplishment of a supervised toothbrushing, with the interdisciplinary team assisting and guiding the students. The interdisciplinary performance allowed the inclusion of knowledge and the integration of the team, besides bringing information and motivation in oral health for the children.
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