Objective:Meningiomas in children is a rare occurrence. Primary intraventricular meningiomas (IVMs) are even rarer with reported incidence of 0.5%–5% of all meningiomas. The aim of the study was to describe the demographic profile, location, surgical approach, complications, and histopathology of six pediatric patients with IVM.Materials and Methods:We retrospectively analyzed all intraventricular tumors operated at our Institute from January 2010 till July 2015. Patients' clinical details and follow-up were obtained from hospital records and scans were obtained from picture archiving and communication system.Results:We found 6 pediatric patients (age ≤18 years) with histopathologically proven IVM. The mean age in this series was 14.6 years. Tumor was most commonly approached through the superior parietal lobule in this series. Gross total excision was achieved in all patients. The blood loss in the series was in the range of 600–2000 ml with a mean of 1100 ml. All were grade 1 meningioma on histopathological examination. Transitional meningioma was the most common histological subtype. None of the patients had a recurrence at last follow-up.Conclusions:Pediatric IVMs are rare tumors. They tend to have a male preponderance in contrast to adults which have a preference for females. Parietooccipital transcortical, transcallosal approach, middle/inferior temporal gyrus approach are the described techniques to tackle such tumors depending on the location of such tumors. Surgeons should watch out for massive blood loss during surgery, especially via the parietooccipital transcortical approach.
s i4NEURO-ONCOLOGY • JANUARY 2018and PARP. Finally we identify increased expression of long neural genes as a likely mechanism for RS in GSC, an observation that correlates closely with recently published studies in neural progenitor cells which demonstrate that DSB arising from replication stress are preferentially located in long neural genes. Several of these genes are overexpressed in our GSC cultures. CONCLUSION: Together these findings support the controversial hypothesis that GSC derive from neural stem cells. Overall, our observations elucidate the mechanism underlying DDR activation and radioresistance in GSC, shed new light on gliomagenesis and cancer stem cell biology, and identify novel therapeutics with potential to improve clinical outcomes by overcoming the inherent radioresistance of GBM.
78% were contacted by telephone, 22% via email63% reported seizure activity, 37% had medication queries 29% attended A&E/admitted to hospital despite our advice71% avoided hospital/GP appointments and/or attending A&E CONCLUSION: Tumour related epilepsy data provided from a large neuro-oncology service at KCH is worthy of being shared. It can highlight the importance of an integrated neuro-oncology service which is accessible to patients through various means: email, telephone, clinics. A personalized service adjusted to the needs of patients. Moreover by utilising the expertise of the Neurologist we have shown that an integrated service may reduce the use of hard-pressed NHS resources in primary care settings and within hospitals.
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