Epidermal nerve fibre (ENF) density and summed length of ENFs per epidermal surface area are reduced, and ENFs may appear more clustered within the epidermis in subjects suffering from diabetic neuropathy compared to healthy subjects. Therefore, it is important to understand the spatial behaviour of ENFs in healthy and neuropathy subjects. By using confocal microscopy data , we study the spatial structure of epidermal nerves by regarding the nerve tree locations as realizations of marked point processes . The termination points of the fibres of a nerve tree are used to define a reactive territory which is taken as a mark for the nerve tree location. We study the differences in the spatial pattern of ENFs between healthy subjects and subjects suffering from mild diabetic neuropathy by using Ripley's K function and the mark correlation function. In addition, we propose a marked sequential point process model for the nerve tree locations. Data are replicated point patterns, where we have several patterns from each subject and from each group.
Recent studies on multivariate control charts are based on Hotelling's T 2 control chart. Due to the fact that the Bayesian control charts in a univariate can be effective on performance of control charts, this paper has proposed the multivariate Bayesian control chart based on economic and economic-statistical design. As finding distribution of Bayesian statistic is too difficult, the Monte Carlo method has been employed in order to determine design optimum parameters (sample size, sampling interval and control limit). Also, artificial bee colony (ABC) algorithm has been applied to search for the optimal design parameters. Ultimately, the performance of the proposed control chart and Hotelling's T 2 were compared for more in-depth investigation.
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