Hydatidosis is a substantial zoonosis infection with a significant socio-economic burden. Surgery is the most effective treatment of hydatidosis. The utilization of scolicidal agents is a method to minimize the risk of distribution of infective protoscoleces during surgery. So far, most of the available scolicidals result in local or systemic side effects. Considering essential oils of Artemisia dracunculus and Satureja sahendica have shown several bioactivities, we decided to characterize A.dracunculus and S.sahendica nanoemulsions and evaluate the scolicidal activity of these two nanoemulsions and the EOs using albendazole as positive control. To reach this goal, 10 3 protoscoleces of E.granulosus in 1 ml medium M199 were exposed to four concentrations of 1, 2, 5, and 10 µg/ml of EOs and nanoemulsions at 30, 60, and 120-minute time points. For all tested plants, a significant effect of the treatments (F5,60=61.47, P<0.001), the time of exposure (F2,120=170.72, P<0.001) and their interaction (F10,120=4.32, P<0.001) were noted. The overall mortality rate in protoscoleces after exposutre to S. sahendica nanoemulsion was significantly higher than other treatments and it was 83.13% (P˂0.05). Among all the tested compounds of the present study, nanoemulsion of S.sahendica demonstrated the highest toxicity on protoscoleces and may serve as a candidate for research and development on novel scolicidas.
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