OTSC is a useful tool for endoscopic closure of various GI lesions, including fistulae and leakages. Future randomized prospective multicenter trials are warranted.

[structure: see text] To study the structural requirements of aminoglycoside binding to nucleic acids, compound 1-an analogue of the naturally occurring nucleoside J-was synthesized. When incorporated into oligodeoxynucleotides, 1 leads to thermal stabilization of the resulting duplexes. The increase in pairing affinity is stronger with complementary RNA than with DNA.

The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow.

Percutaneous endoscopic gastrostomy (PEG) is a common practice for long-term nutrition of patients who are unable to take oral food. We report of an 85-year old man with a history of recurrent larynx carcinoma and hemicolectomy many years ago due to unknown reason. Laryngectomy was indicated. Preoperatively a PEG was inserted endoscopically after an abdominal ultrasonography without abnormal findings. Few months after PEG insertion, the patient was evaluated for diarrhea and insufficient feeding without signs of infection or peritonism. An upper endoscopy and computed tomography scan confirmed a buried bumper syndrome with migration of the PEG tube into the colon as a rare complication. He underwent successful colonoscopic removal of the internal bumper and closure of the colonic orifice of the fistula with the over-the-scope-clip system (OTSC). OTSC is an endoscopic device for treatment of bleeding, perforation, leak and fistula in the gastrointestinal tract. To the best of our knowledge, this is the first report of the use of OTSC for colonoscopic closure of a gastrocolocutaneous fistula due to a buried bumper syndrome with transcolonic PEG tube migration.

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Question: A 25-year-old Eritrean woman was admitted with a 4-week history of abdominal pain and weight loss of 10 kg without diarrhea and without a family history of neoplasia. Physical examination was significant for mild tenderness over the right abdomen. Hemoglobin was decreased with 96 g/L (reference range, 120-160 g/L) and C-reactive protein elevated at 114 mg/L (reference value, <8 mg/L) with a normal white cell count. A contrast-enhanced computed tomography scan of the chest and abdomen showed a polypoid hyperdense intraluminal mass measuring 25 mm in the ascending colon (Figure A) without metastases. Colonoscopy revealed a pedunculated polyp with a head size of 25 mm with ulcerated surface and a stalk size of 10 mm in the ascending colon (Figure B). The polyp was lifted after submucosal injection into the stalk with 1:100,000 adrenaline, saline, indigocarmine, and succinylated gelatine (Figure C). Hot snare (25-mm snare) polypectomy and bleeding prevention with clips were successfully performed with retrieval of the polyp for histopathologic examination (Figure D, E).What is the diagnosis? See the Gastroenterology web site (www.gastrojournal.org) for more information on submitting your favorite image to Clinical Challenges and Images in GI.

Given the differential binding capacity and the favorable radioactivity pattern, (18) F-RB390 represents the portrayal of the first imaging ligand with predictive potential for mutant T877A-AR in prostate cancer for guiding therapy. Prostate 75:348-359, 2015. © 2014 Wiley Periodicals, Inc.

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