Background: Atopic dermatitis is a chronic inflammatory disease which can recur at adulthood particularly in people with genetic predisposition like asthma or other hypersensitivities. It has an adverse impact on the daily life of patients and hence, it is clear that appropriate treatment is necessary; hence the study was carried out to evaluate the efficacy of topical agents Tacrolimus and Corticosteroids. Materials and Methods: This Prospective Observational Study was carried out in 108 patients recruited from the Department of Dermatology, Cosmopolitan Hospital, Thiruvananthapuram for a period of 6 months. A written informed consent was taken. Out of the 108 patients, 54 patients received Topical Tacrolimus and the remaining 54 patients received Topical Corticosteroids. Eczema Area Severity Index (EASI) score analysis was performed at base line and after 2 weeks of drug therapy. Results: The result of the study was developed by comparing EASI scores of all the patients. Two statistical methods were used for developing the result. Independent 't' test for Between Group comparison and Paired 't' test for Within Group comparison. From the statistical evidences, it is deduced that both the drugs are effective for treatment of atopic dermatitis (P -value < 0.05). After comparing both the drugs, it was found that Corticosteroids are more effective than Tacrolimus (P -value < 0.05). Conclusion: From this study, it has been concluded that both the drugs Tacrolimus and Corticosteroids have a significant role in treatment of atopic dermatitis. But on comparison of both the agents, Corticosteroids are found to be more efficacious than Tacrolimus.
Background: Atopic dermatitis is an acute, sub-acute or chronic relapsing skin disorder characterized by intense itching, pruritus and oozing. It adversely affects the routine activities of patients for which effective treatment is to be provided along with proper counselling. The aim of the current study was to evaluate the impact of patient counselling on quality of life (QoL).Methods: A prospective study was conducted in 108 patients recruited from the Department of Dermatology for a period of 6 months. A written informed consent was taken. Out of the 108 patients, 54 patients received tacrolimus and the remaining received corticosteroids. The collected data was analysed and presented. Data was collected by using a suitably designed proforma. Dermatology life quality index (DLQI) was used for assessing QoL. Patients were counselled regarding the disease, drugs and lifestyle modifications using patient information leaflet (PIL).Results: The current study found that patient counselling was effective for both the groups with a p value <0.05. The effect of disease in quality of life improved from severe to mild in both groups (prior to counselling QoL mean value of 2.93±0.61 shifted to 1.18±0.71 post counselling). In the tacrolimus group, QoL mean value of 2.81±0.61 shifted to 0.98±0.71 after counselling. In the corticosteroids group, a shift from a mean QoL value of 3.05±0.59 to a mean of 1.38±0.65 was observed post counselling.Conclusions: The provision of effective counselling was found to have a profound impact on improving patient’s quality of life. A transition from severe effects of the disease to milder effects of the disease on quality of life was observed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.