1,4-Disubstituted bis-chromenyl triazole hybrids 5a-m have been synthesized in a three-step reaction sequence from 4-(bromomethyl)-2H-chromen-2-ones 3a-m. The intermediate azides 4a-m underwent a regioselective 1,3-dipolar cycloaddition with a 2H-chromen-2-one linked acetylenic dipolarophile in the presence of Cu (II)/ascorbate/ water/n-butanol reaction medium. Three compounds 5h-j exhibited 6.25 lg/mL MIC against M. tuberculosis. Among the compounds screened for antifungal activity, lowest MIC of 6.25 lg/mL was observed for 5c against A. niger that also exhibited DNA cleavage observed by agarose gel electrophoresis. All the compounds were moderately active against both Gram-positive and Gramnegative bacterial strains. The cytotoxic effect of potent compounds on normal cells (V79 and HBL100) was assessed by MTT assay.

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Abstract.A new synthetic strategy for the construction of dihydrofuro coumarins and quinolones has been developed by a three component reaction. Formation of 2,3-dihydrofuran ring and the trans orientation is supported by 1 H-NMR and confirmed single X-ray diffraction studies.

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A Click Chemistry Approach for the Synthesis of Mono and Bis Aryloxy Linked Coumarinyl Triazoles as Antitubercular Agents. -A wide range of mono-and bis-triazole coumarin hybrids are formed from chromene-2-one derivatives and propargyl ethers employing a Click chemistry modified protocol for Azide-Alkyne cycloadditions. The antitubercular screening shows moderate activities for the mono aryloxy compounds (III) and significant activities for compounds (V). Bis-derivative (Va) shows the highest activity. -(ANAND, A.; NAIK, R. J.; REVANKAR, H. M.; KULKARNI*, M. V.; DIXIT, S. R.; JOSHI, S. D.; Eur. J. Med. Chem. 105 (2015) 194-207, http://dx.

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In the title compound, C15H19NO5, an intra­molecular O—H⋯O hydrogen bond links the hy­droxy­ethyl side chains, forming a seven-membered ring. In the crystal, mol­ecules are linked into chains via O—H⋯O hydrogen bonds along the b axis. Further, mol­ecules are linked by weak inter­molecular C—H⋯O and π–π stacking inter­actions [centroid–centroid distance = 3.707 (4) Å].