Highlight:
It was proven that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern.
There are three possible mechanisms of renal injury in COVID-19 infection: direct viral mediated, prolonged cytokine storm mediated, and drug-induced renal injury.
There is no targeted drug therapy in the treatment of renal injury, while Chinese Herbal Medicine can be a potential solution.
Huang Qi, Fu Ling, Di Huang, Shan Yao and Bai Zhu are the core herbs in Chinese Herbal Medicine to treat renal injury.
Chinese Herbal Medicine may act on PTGS2, PTGS1, IL6 and CASP3, etc., to prevent the pharmacological and non-pharmacological COVID-19 related renal injury.
The novel coronavirus disease 2019 (COVID-19) epidemic is threatening public health security in China. Owing to the severity of this epidemic, identifying a proper treatment for COVID-19 is crucial. Although the Quing-Fei-Pai-Du (QFPD) decoction preliminary displayed promising clinical efficacy, its potential biological mechanism has not been explored for further pharmaceutical development and treatment. Through systems pharmacology and virtual screening approaches, we explored the potential mechanism of action and the active ingredients of the QFPD decoction for COVID-19 treatment. A ingredients-targets dataset was generated. ADME/Tox and molecular docking analyses were conducted to screen the potentially-active ingredients. Protein-protein interaction network and the detection algorithm were applied to dynamically identify functionally-relevant protein groupings. Totally, 705 ingredients and 1,489 targets were obtained. Docking revealed that 40 components could be promising active ingredients, 6 of which (Neohesperidin, Naringenin, Liquiritigenin, Apigenin, Isoquercitrin and Herbacetin), were highlighted according to the comprehensive analysis. The enrichment analysis of the highlighted ingredients showed that several significant pathways could be highly related to their mechanisms of action, such as response to oxygen levels, response to oxidative stress, and blood circulation. Overall, our findings suggest the promising effects of the QFPD decoction for COVID-19 treatment. Further experimental and clinical verifications are needed.Authors Xiting Wang and Meng Liu contributed equally to this work.
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