Background
Low signal‐to‐noise ratio (SNR) has been a major limiting factor for the application of higher‐resolution diffusion‐weighted imaging (DWI). Most of the conventional denoising models suffer from the drawbacks of shallow feature extraction and hand‐crafted parameter tuning. Although multiple studies have shown the promising applications of image denoising using convolutional neural networks (CNNs), none of them have considered denoising multiple b‐value DWIs using a multichannel CNN model.
Purpose
To present a joint denoising CNN (JD‐CNN) model to improve the SNR of multiple b‐value DWI.
Study Type
Retrospective technical development.
Population
Twenty healthy rats and two rats with clinically confirmed focal cortical dysplasia were included to evaluate the performance of the proposed method.
Field Strength/Sequence
11.7T MRI, a multiple b‐values DWI sequence.
Assessment
The total variation (TV) and BM3D denoising methods were also performed on the same dataset for comparison. Peak SNR (PSNR) and normalized mean square error (NMSE) were calculated for the assessment of image qualities.
Statistical Tests
A paired Student's t‐test was conducted to compare the diffusion parameter measurements between different approaches. P < 0.01 was considered statistically significant.
Results
Simulation results showed substantial improvement of image quality after JD‐CNN denoising (PSNR of original image: 23.15 ± 1.77; PSNR of denoised image: 42.94 ± 2.12). The proposed method outperforms the state‐of‐the‐art methods on high b‐value DWIs in terms of PSNR (TV: 33.51 ± 0.83, BM3D: 35.12 ± 0.94, JD‐CNN: 46.52 ± 0.98). In addition, the NMSE of the estimated apparent diffusion coefficient (ADC) reduces from 0.72 ± 0.13 to 0.45 ± 0.06 (P < 0.01) with the application of the JD‐CNN model.
Data Conclusion
The proposed method is able to remove noise with a wide range of noise levels in multiple b‐value DWI and improve the diffusion parameter estimation. This shows potential clinical promise.
Level of Evidence: 2
Technical Efficacy Stage: 2
J. Magn. Reson. Imaging 2019;50:1937–1947.
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