The rhodium (II) complexes Rh2(tfa)4.2(tfac) and Rh2(tfacam) 4 (tfacam CF3CONH-,tfa CF3COO-, tfac CF3CONH2) were synthesized and characterized b) microanalysis and electronic and vibrational spectroscopies. Rhz(tfacam)4 was tested both in vitro (U937 and K562 human leukemia cells and Ehrlich ascitic tumor cells) and in vivo for cytostatic activity and lethal dose determination, respectively. This is the first rhodium tetra-amidate to have its biological activity evaluated. The LDs0 value for Rh2(tfacam)4 is of the same order as that of cisplatin, and it was verified that the rhodium complex usually needs lower doses than cisplatin to promote the same inhibitory effects.
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