Aim:To verify the association of the TNF-α, IL-6, and IL-10 polymorphisms with chronic temporomandibular disorder pain development in female elderly patients. Methods: Participants were evaluated according to Diagnostic Criteria for Temporomandibular Disorders. The genomic DNA was extracted from blood according to the Salting Out method followed by a quantification using the NanoDrop spectrophotometer. The -308G/A TNF-α polymorphism analysis was performed by the polymerase chain reaction-restriction fragment length polymorphism technique, the determination of -174G/C IL-6 polymorphism was performed by polymerase chain reaction, and the evaluation of the -1082A/G IL-10 polymorphism was carried out by polymerase chain reactionallele-specific amplification. Data were analyzed using the BioEstat 5.3 software. Results: The -308G/A TNF-α polymorphism showed a significant difference when genotypes of cases with chronic temporomandibular disorder pain and controls were compared (p = .025). There was a lack of association regarding the -174G/C IL-6 polymorphism (p = .286) however, a positive association between the -1082A/G IL-10 polymorphism with chronic temporomandibular disorder was observed (p = .020).
Introduction Temporomandibular disorder (TMD) is a pathology of the stomatognathic system, considered the main cause of non-dental orofacial pain. Several signs and symptoms are present in the face from this pathology, and among them, there is the possibility of pain in the joint and associated regions. Pain is defined by International Association Study of Pain as an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage. Although it relates to adaptive processes, it can cause adverse effects on social and psychological function and well-being, influenced to different degrees by biological, psychological and social factors. Individuals with chronic pain, further to the pains, have oscillation in their emotional behaviors and sleep disturbances. The anxiety and depression in the pathogenesis of temporomandibular disorders have been investigated since the entry of Research Diagnostic Criteria (RDC) for TMD in 1992, approached in Axis II of this instrument. Studies indicate that the health of the individual and quality of life are influenced negatively by the pain and/or for the stress caused by TMD, which can compromise daily activities, cognitive and affective balance, the physical activities and sleep. As shown above, TMD is considered an important health problem nowadays, and is also important to consider the psychological aspects related to it and the impacts on the quality of the individuals affected by this disorder. Objective The aim of this study is to analyze the correlation of sleep, pain and anxiety in individuals with TMD. Methods This work is a cross-sectional study that uses data from research realized in Federal University of Pernambuco (UFPE), approved by the Ethics and Research Committee and labeled under the number 81287.9.0000.5208... (To see the complet abstract, please, check out the PDF.)
Introduction: Temporomandibular disorder (TMD) refers to a group of conditions that compromise the harmonious movement and function of the temporomandibular joint, masticatory muscles, and associated structures. The etiopathogenesis of TMD is multifactorial but not well-understood, with the role of genetic factors still being unclear. Objective: This review aims to summarize the results of studies that evaluated TNF-α levels and the -308G/A TNF-α polymorphism in TMD patients. This study emphasizes the importance of a more selective treatment involving TNF-α inhibitors that can potentially reduce inflammation and pain, and improve quality of life. Methods: The MEDLINE/PubMed database, Cochrane Library, and Web of Science database were searched for case-control studies published until September 2020 that compared levels of TNF-α or presence of its -308G/A polymorphism in TMD patients and healthy individuals. Results: Six case-control studies were identified with a total of 398 TMD patients, aged between 12 and 78 years. The control group consisted of 149 subjects, aged between 18 and 47 years. The occurrence of TMD was predominant in females. Majority of studies found high TNF-α levels in TMD patients, compared to the control group. One of these studies found a positive correlation between the GA genotype and the development of TMD. Conclusion: Majority of the TMD patients showed elevated TNF-α levels, and a possible explanation for this could be the presence of the -308G/A polymorphism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.