Calvarial defects with a diameter of 5.0 mm could be considered as a CSD. However, there is a necessity for further standardization of the rat calvaria model to enable more accurate comparison among future studies.

Background. Genetic polymorphisms in certain cytokines and chemokines have been investigated to understand why some individuals display implant flaws despite having few risk factors at the time of implant. Purpose. To investigate the association of genetic polymorphisms in interleukin- (IL-) 10 [-1082 region (A/G)] and RANKL [-438 region (A/G)] with the failure of dental implants. Materials and Methods. This study included 90 partially edentulous male and female patients who were rehabilitated with a total of 245 Straumann dental implants. An implant was considered a failure if any of the following occurred: mobility, persistent subjective complaint, recurrent peri-implant infection with suppuration, continuous radiolucency around the implant, probing depth ≥ 5 mm, and bleeding on probing. Buccal mucosal cells were collected for analysis of RANKL438 and IL-10. Results. The implant success rate in this population was 34.4%. The mutant allele (G) in RANKL had an incidence of 52.3% and mutant allele (A) in IL-10 was observed in 37.8%. No statistically significant difference was detected between the failure of the implant and the genotypes and allelic frequencies. Conclusion. No association was detected between the genetic polymorphisms of RANKL (-438) and IL-10 (-1082) and the failure of dental implants in the population studied.

The aim of the present study was to evaluate the presence of the periodontal pathogens that form the red complex (Tannerella forsythia, Porphyromonas gingivalis and Treponema denticola) and Aggregatibacter actinomycetemcomitans in patients with chronic periodontitis. The sample consisted of 29 patients with a clinical and radiographic diagnosis of chronic periodontitis based on the criteria of the American Academy of Periodontology (3). Samples for microbiological analysis were collected from the four sites of greatest probing depth in each patient, totaling 116 samples. These samples were processed using conventional polymerase chain reaction, which achieved the following positive results: 46.6% for P. gingivalis, 41.4% for T. forsythia, 33.6% for T. denticola and 27.6% for A. actinomycetemcomitans. P. gingivalis and T. forsythia were more prevalent (p < 0.05) in periodontal pockets ≥ 8 mm. The combinations T. forsythia + P. gingivalis (23.2%) and T. forsythia + P. gingivalis + T. denticola (20.0%) were more frequent in sites with a probing depth ≥ 8 mm. Associations with the simultaneous presence of A. actinomycetemcomitans + P. gingivalis, A. actinomycetemcomitans + T. forsythia, P. gingivalis + T. forsythia and T. forsythia + T. denticola were statistically significant (p < 0.05). It was concluded that the red complex pathogens are related to chronic periodontitis, presenting a higher occurrence in deep periodontal pockets. Moreover, the simultaneous presence of these bacteria in deep sites suggests a symbiotic relationship between these virulent species, favoring, in this way, a further progression of periodontal disease.

In order to determine the influence of social class on clinical reasons for tooth loss in

O objetivo deste estudo foi estimar a prevalência de autoavaliação negativa de saúde bucal e fatores associados entre adultos em áreas de assentamento rural. A amostra probabilística consistiu de 557 adultos entre 20 a 59 anos em áreas de assentamento rural no Estado de Pernambuco, Brasil. A variável dependente foi autoavaliação da condição de saúde bucal e as independentes foram: características demográficas, de predisposição/disponibilidade de recursos, comportamentos relacionados à saúde bucal, condições objetivas e subjetivas relacionadas à saúde bucal. Foram estimadas as razões de prevalência bruta e ajustada por meio de regressão de Poisson. A prevalência de autopercepção negativa da saúde bucal foi de 70,5%. A autoavaliação negativa da saúde bucal foi mais prevalente em indivíduos mais jovens, de baixa escolaridade, entre as mulheres, e entre os de cor preta e parda. Os preditores da autoavaliação negativa da saúde bucal foram a cor da pele, a necessidade autorreferida de tratamento odontológico e o impacto das condições de saúde bucal na qualidade de vida.

Aim: The aim of the present study was to evaluate the impact of oral problems on the quality of life of individuals with type 2 diabetes mellitus (DM2). Methods: A population-based, cross-sectional study was conducted with a random sample of 302 individuals with DM2 who answered the Oral Health Impact Profile 14 (OHIP-14) questionnaire as well as a questionnaire addressing socioeconomic and oral health characteristics. After filling out the questionnaires, the participants were submitted to a clinical dental examination Periodontal diseases, dental caries and edentulism. Data analysis involved descriptive statistics, bivariate analysis and logistic regression. Results: The prevalence of impact on oral health-related quality of life (OHRQoL) was 47%. In the multivariate analysis, the variables that remained significantly associated with a negative impact on quality of life were xerostomia (OR= 2.15; 95% CI: 1.07-4.30), denture need (OR= 3.71; 95% CI: 1.17-11.73) and periodontitis (OR= 5.02; 95% CI: 2.19-11.52). Conclusion: The prevalence rate of impact on OHRQoL was high in the sample studied. Xerostomia, denture need and periodontitis posed a risk of negative impact on the quality of life of individuals with DM2, independently of socioeconomic status.

Fatores associados às perdas dentárias entre adultos em áreas rurais do estado de Pernambuco, BrasilFactors associated with tooth loss among adults in rural areas in the state of Pernambuco, Brazil

AB STRACT:A cross-sec tional study was car ried out to an a lyze tooth loss re sult ing from car ies in re la tion to the number of times the ex tracted tooth had been re stored, the type of car ies di ag nosed (pri mary or sec ond ary), and so cio economic in di ca tors of pa tients from the city of Recife, Brazil. Ten pub lic health cen tres and ten cen tres as so ci ated with health in sur ance com pa nies were ran domly se lected. The size of the sam ple was cal cu lated us ing a stan dard er ror of 2.5%. A con fi dence in ter val of 95% and a 50% prev a lence of rea sons for ex trac tions were used for cal cu lat ing the sample. The min i mum size of the sam ple for meet ing these re quire ments was 381 pa tients. Pa tients were ran domly selected from the list of adults reg is tered at each cen tre. A to tal of 410 pa tients were in vited to take part in the study. The re sponse rate was 100%, but 6 pa tients were ex cluded due to in com plete ness of data in the ques tion naire ap plied. An as sess ment was made to ob tain the num ber of de cayed, miss ing or filled teeth (DMFT in dex) and the rea sons for extrac tion. The re sults showed a highly sig nif i cant (p < 0.001) re la tion ship be tween the num ber of times the tooth in dicated for ex trac tion had been re stored and the rea son for ex trac tion be ing car ies. Fur ther more, the ma jor ity of teeth ex tracted due to car ies had been re stored two or more times. A highly sta tis ti cally sig nif i cant as so ci a tion was also observed be tween one in di ca tor of use of den tal ser vices (F/DMFT) and ex trac tion due to car i es (p < 0.001). The find ings ques tioned the be lief that tooth loss can be pre vented in the gen eral pop u la tion by merely pro vid ing re stor ative treatment. DESCRIPTORS: Den tal car ies; Den tal health ser vices; Tooth loss; So cio eco nomic fac tors; Den tal res to ra tion fail ure. RE SU MO:Um es tu do trans ver sal foi con du zi do com o ob je ti vo de ana li sar a per da den tá ria, pela ra zão cá rie, em re lação ao nú me ro de ve zes que o den te ex tra í do foi res ta u ra do, tipo de cá rie di ag nos ti ca da (pri má ria ou se cun dá ria) e indi ca do res so ci o e co nô mi cos de pa ci en tes na ci da de de Re ci fe, Bra sil. Dez cen tros do Sis te ma Pú bli co de Saúde e dez per ten cen tes a em pre sas de con vê ni os fo ram sor te a dos. O ta ma nho da amos tra foi cal c u la do uti li zan do-se um erro padrão de 2.5%. O in ter va lo de con fi an ça de 95% e uma pre va lên cia de ra zões de ex tra ção na or dem de 50% fo ram usados para o cál cu lo da amos tra. Uma amos tra mí ni ma re que ri da de 381 pa ci en tes foi cal cu la da, sen do exa mi na dos um to tal de 410 pa ci en tes sor te a dos da lis ta de aten di men to dos pos tos. 100% dos pa ci en tes con cor da ram em par ti ci par da pes qui sa, con tu do, seis pa ci en tes fo ram ex clu í dos do es tu do por apre sen ta rem da dos in com ple tos no ques ti o ná rio apli ca do. Os pa ci en tes fo ram exa mi na dos para a ob ten ção do CPOD e da...