A Doença de Alzheimer (DA) ocorre quando, em algumas pessoas, algumas proteínas como a proteína Tau e fragmentos da proteína APP, os peptídeos β-Amiloide, se juntam em agregados conforme a pessoa envelhece, gerando neurotoxicidade, o que se apresenta, entre outras coisas, como déficits cognitivos, funcionais e comportamentais, interferindo sobretudo na memória. A DA até o momento não tem cura, mas existem tratamentos que visam retardar seu avanço e prevenir seus sintomas. Um desses tratamentos é o Neurofeedback, que atua na alteração de padrões cerebrais estimulando a neuroplasticidade, esta que atua permitindo o reestabelecimento de algumas funções cerebrais que foram debilitadas. Neste capítulo, revisamos de forma narrativa a res-
Background: Alzheimer’s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor. Objective: To investigate the association between APOE4 and BCHE-K as a risk factor for AD. Methods: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele. Results: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558. Conclusion: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.
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