The dental caries is not simply a continuous and unidirectional process of the demineralization of the mineral phase, but a cyclic event with periods of demineralizations and remineralisation. The remineralization process is a natural repair mechanism to restore the minerals again, in ionic forms, to the hydroxyapatite (HAP) crystal lattice. It occurs under near-neutral physiological pH conditions whereby calcium and phosphate mineral ions are redeposited within the caries lesion from saliva and plaque fluid resulting in the formation of newer HAP crystals, which are larger and more resistant to acid dissolution. Numerous types of remineralizing agents and remineralizing techniques have been researched and many of them are being used clinically, with significantly predictable positive results. The recent researches on remineralization are based on biomimetic remineralization materials, having the capability to create apatite crystals within the completely demineralized collagen fibers.How to cite this articleArifa MK, Ephraim R, et al. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent 2019;12(2):139–144.
Background: Pleasant tasting syrups have a long history of use in pediatric practice to aid compliance with medication. Pharmaceutical firms sweeten liquid drug preparations with sucrose to increase the palatability which causes dental caries and erosion in children. In pediatric population, the commonly used esthetic restorative materials are glass ionomers, compomers or composites. Hence solubility of dental restorative materials are of considerable clinical importance and cannot be overlooked. Aims and objectives of current study were to evaluate the effect of commonly used pediatric drugs on the surface solubility of pediatric restorative materials.Methods: The study was conducted on 40 disc shaped specimens of GIC and composite immersed in artificial saliva and pediatric drugs, at 370C for 7 days to determine the solubility in pediatric drug formulations. The solubility of the specimens was calculated by a given formula by comparing the initial and final masses of the specimens.Results: In both GIC and Composite groups higher solubility was seen with paracetamol drug formulations. The mean solubility value of GIC was 0.14±0.02 and that of composite was 0.07±0.035, in paracetamol drug formulations.Conclusions: From the above experimental study it can be concluded that the solubility of restorative materials were comparatively higher in pediatric liquid medications with low pH. Among the drugs paracetamol showed increased erosive effects leading to solubility.
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