Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included. By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72). Subgroup analysis showed that VDD also was associated with poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05), short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and sleepiness (OR: 1.36, 95% CI: 1.12, 1.65). Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep. This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.

Cerebellar degeneration-related protein 1 antisense (CDR1as) is an important member of the circRNAs family, also known as cirs-7. Its main function in vivo is to act as a mir-7 sponge. Accumulated studies show that CDR1as is closely related to various diseases, especially cancer. Our analysis show that CDR1as expression in human cancer is significantly associated with poor overall survival (hazard ratio [HR] = 2.50, 95% confidence interval [CI] = 2.06–3.04; p &lt; 0.00001) and that high CDR1as expression is associated with the tumor node metastasis stage (odds ratio [OR] = 2.13, 95% CI = 1.63–2.78; p &lt; 0.00001), and distant metastasis (OR = 3.50, 95% CI = 1.90–6.64; p &lt; 0.00001). Furthermore, the results reveal the prognostic significance of CDR1as in neoplasms of the digestive system (HR = 1.69, 95% CI = 2.14–2.71; p &lt; 0.001), colorectal cancer (HR = 1.34, 95% CI = 1.96–2.85; p &lt; 0.001), and non-small cell lung cancer (HR = 2.40, 95% CI = 3.42–4.83; p = 0.008). In this study, we summarize in detail the latest research findings and demonstrate the function and regulatory mechanism of CDR1as in various cancer processes, and its potential as a biomarker for cancer prevention and prognosis.

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Coronavirus Disease 2019 (COVID-19) has caused a pandemic globally since its outbreak in 2019. As an important port city with prosperous foreign trade, Shanghai has been under severe pressure to prevent the input of COVID-19. With this in mind, solid policies and measures have always been taken in Shanghai to control the input of COVID-19 strictly. In March 2022, the SARS-CoV-2 Omicron variant swept Shanghai, and then the home office order was rapidly carried out in most of the districts. This article focuses on quantifying the changes in concentrations of PM10 and PM2.5 in Shanghai after implementing the home office order and exploring the spatial-distribution characteristics and time trend of the impact of the home office order on airborne particulate matters (PMs) through an interrupted-time-series (ITS) analysis. This study found that PM10 and PM2.5 decreased by 31.40 μg/m3 (p = 0.028) and 10.33 μg/m3 (p = 0.276), respectively, with the fastest decrease speed in the first 10 days of the home office order. Meanwhile, the changes in PM concentrations in eastern areas such as Fengxian District and Chongming District are less than those in central and western areas of Shanghai. Therefore, it can be concluded that implementing the home office order for 10 days could effectively cut down PM concentrations, and the reduction values can be affected by spatial difference and time factor.