Convenient Synthesis of Aminopyridinecarboxylic Acids. -Monoamination of dibromopyridines (I) and (VIII) followed by carbonylation and subsequent hydrolysis of methyl esters (VI) and (X) furnish (alkylamino)pyridinecarboxylic acids (VII) and (XI) in satisfactory to good yields, though the 3,5-dibromopyridine (VIII) reacts more slowly. Significant formation of the diamino product or other by-product is not observed, so this procedure may be suitable for large-scale synthesis. -(OKAMOTO*, I.; TERASHIMA, M.; YOSHIOKA, R.; MURAMATSU, T.; KOJIMA, S.; INOUE, H.; TAKAHASHI, M.; MORITA, N.; TAMURA, O.; Heterocycles 83 (2011) 10, 2343-2352, http://dx.doi.org/10.3987/com-11-12290 ; Showa Pharm. Univ., Machida, Tokyo 194, Japan; Eng.) -H. Hoennerscheid 07-128
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.