DNA-encoded library (DEL) technology has become widely used in drug discovery research. The construction of DELs requires robust organic transformations that proceed in aqueous media under mild conditions. Unfortunately, the application of water as reaction medium for organic synthesis is not evident due to the generally limited solubility of organic reagents. However, the use of surfactants can offer a solution to this issue. Oil-in-water microemulsions formed by surfactant micelles are able to localize hydrophobic reagents inside them, resulting in high local concentrations of the organic substances in an otherwise poorly solvated environment. This review provides a conceptual and critical summary of micellar synthesis possibilities that are well suited to DEL synthesis. Existing examples of micellar DEL approaches, together with a selection of micellar organic transformations fundamentally suitable for DEL are discussed.
A visible
light induced palladium-catalyzed fluoroalkylation method
was developed. The Heck-type alkyl coupling reaction enables the introduction
of trifluoroethyl, difluoroethyl and other fluoroalkyl fragment into
styrenes under mild reaction conditions without the use of additional
photosensitizers and ensures access to fluoroalkylated olefins on
a broad scale.
Micellar catalysis offers a green alternative media for catalytic transformations by solubilization of hydrophobic organic compounds. Biosurfactants represent a sustainable alternative to synthetic surfactants due to their biodegradability, low toxicity,...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.