The synthesis and resolution of a class of chiral organic fluorophores, axially chiral 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (Ax*-BODIPY), is described. Ax*-BODIPYs were prepared through a modular synthesis combined with a late stage Heck functionalisation. Resolution was achieved by preparative chiral HPLC. Absolute stereochemical assignment was performed by comparison of experimental ECD spectra with TD-DFT calculations.

2,2,2-Trichloro-1-arylethanones undergo high yielding reductions to the corresponding 2,2-dichloro-1-arylethanones in the presence of RMgX. A single electron transfer mechanism for the reaction is proposed based on trapping experiments. Reaction of the intermediate enolates with a range of electrophiles is described, providing a convenient route to substituted α,α-dichloro-β-hydroxyketones and related molecules.

2,2,2-Trichloro-1-aryl-ethanones can be reduced by RMgX to the corresponding 2,2-dichloro-1-arylethen-1-olates and trapped with a range of electrophiles resulting in either reduction, reduction/aldol, reduction/Claisen condensation or reduction/aldol-Tishchenko products. In addition we demonstrate that 2,2-dichloro-1-arylethen-1-olates undergo counter-ion controlled Darzens condensations, which can be followed by a thermal rearrangement as a route to 1,3-diaryl-3-chloropropane-1,2-diones.

Direct oxidation of eugenol has been done using potassium permanganate. This research attempts to produce benzyl carboxylic acid, an important intermediate reactant for isoflavone synthesis, directly by breaking the  bond of allillic group attached to eugenol. The oxidation procedures were adopted from Wahyuningsih and Kusumaningsih anetol oxidation reactions. There were three modifications done i.e. one polar system of the oxidation environment, variation of time of reflux and temperature. Eugenol was firstly diluted in water by converting to its salt type and then oxidized using KMnO 4 at 75 o C for 4 hours. The expected acid was separated by acidifying using sulfuric acid.The result showed that direct oxidation of eugenol using modified method of Wahyuningsih gave only a vicinal diol which undergoes polymerization into product in 80% yield with 83% purity. However, variation of time of reflux of Wahyuningsih method showed the same result with Kusumaningsih method as brown oily viscous liquid. The product was only 38% purity.

Reduction of 2,2,2-Trichloro-1-arylethanones by RMgX: Mechanistic Investigation and the Synthesis of Substituted ,-Dichloroketones. -Title compounds (I) and (III) undergo high yielding reductions to the corresponding 2,2-dichloro-1-aryl--ethanones (II) and (IV) in the presence of Grignard reagents. A single electron transfer mechanism is proposed based on trapping experiments. Moreover, reaction of the intermediate enolates with electrophiles such as aldehydes (V) is described, providing substituted ,-dichloro--hydroxyketones (VI) and related molecules. -(ESSA, A. H.; LERRICK, R. I.; TUNA, F.; HARRINGTON, R. W.; CLEGG, W.; HALL*, M. J.; Chem. Commun. (Cambridge) 49 (2013) 27, 2756-2758, http://dx.doi.org/10.1039/c3cc39147g ; Sch. Chem., Univ. Newcastle, Newcastle upon Tyne NE1 7RU, UK; Eng.) -S. Karsten 28-107

Recent advances in cheminformatics and bioinformatics research have generated software and computational tools for molecular modeling and visualization that can be incorporated to improve chemistry teaching and learning in high school. Nevertheless, there have never been any study simultaneously reporting chemistry teachers' awareness, understanding, and confidence toward contemporary computer-aided molecular modeling and visualization tools. This study examined 32 high school chemistry teachers' knowledge, understanding and confidence toward nine new computational programs on molecular modeling and visualization namely ChemDraw, HyperChem, UCSF Chimera, Marvin Sketch, PsiPred, MBC (PS2), Rampage, Vienna RNA Package and Mode RNA following two days of professional workshop-based training. After completing the training and assessments, the teachers showed an enhancement in awareness, understanding, and confidence toward those nine computational programs. Intensive activities consisting of theoretical lectures, hands-on practices, assignments, and case study presentations seem to provide valuable resources to the increase in teachers' knowledge, understanding, and skill that incorporates computational technology. Hence, the impact of this research pointed toward the value of teachers' professional development that creates a platform to reduce the barriers of access, resources, knowledge, and skills. This study is expected to help improving teachers' awareness, understanding, and confidence necessarily required for further implementation of available technology for instructional purposes.

A new T-grafting photosensitizer of Dye-Sensitized Solar Cell (DSSC) has been developed by aligning Donor-Acceptor (D-A) group in an axially chiral BODIPY. Synthesis of the dye was conducted over a linear approach involving one-pot, non-oxidative synthesis of 1,3,5,7-tetramethyl-8-(o-methoxyphenyl)BODIPY, bromination, and finally C2/C6 ethyl acrylate Pd-Heck coupling to produce 65% of 2-ethylacrylic-1,3,5,7-tetramethyl-8-(o-methoxyphenyl)BODIPY (BOD-8) and 35% of 2,6-diethylacrylic-1,3,5,7-tetramethyl-8-(o-methoxyphenyl)BODIPY (BOD-9), both characterized by the appearance of acrylic alkenes at 6.05, and 7.63 ppm for BOD-8, and the additional 5.43, 7.80 ppm doublet peaks for BOD-9. The resulting dye showed excellent photon harvesting-related photovoltaic properties and electronic injection and regeneration processes where the acrylic esters were found to be the Donor and the aryl was the Acceptor. Eventually, the dye produced a current at 0.5% efficiency, similar to the horizontal D-A DSSC photosensitizer design.

Seeking Nonsteroidal anti-inflammatory painkillers are in the race due to the escalating cases of the life-threatening COVID-19 pandemic. Those current Nonsteroidal Anti-inflammatory Drugs (NSAIDs) used as an inflammation adjunct treatment on the COVID-19 patients including Paracetamol, Ibuprofen, and Celecoxib, are still under dispute offering emergency development of a new potent NSAID. Meanwhile, a well-known COX-2 selective anti-inflammation 2,4,5-trimethoxybenzaldehye has not been developed further in terms of its synthetic methodology and as well its pharmacokinetic studies. Here, an article on the synthesis of 2,4,5-trimethoxybenzaldehyde from Indonesia Sweet Flag (Acorus calamus) and as well its pharmacokinetic properties studied through in silico calculation was published. A typical Asian tetraploid calamus oil was yielded in 90% pure after doing reduced pressure distillation of the crude Indonesian Sweet flag oil. Submission of that oil into a very cheap DIY ozone machine produced 95% of pure 2,4,5-trimethoxybenzaldehyde just in 10 minutes ozonised. The in silico Adsorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) prediction using free access ADMETlab 2.0 web server strongly recommended the 2,4,5-trimethoxybenzaldehyde to be an orally administered NSAID candidate.