Purpose To evaluate the characteristics of posterior vitreous cells in patients with uveitis on the classification basis using spectral domain optical coherence tomography (SD-OCT). Methods In this retrospective chart review, all eyes were classified into three groups: infectious uveitis (IFU, n=7), noninfectious granulomatous uveitis (NIGU, n=13), and noninfectious nongranulomatous uveitis (NINGU, n=13). We measured the size, number, and density of vitreous hyperreflective particles in the posterior vitreous area that was defined as the space between the vitreous top and the internal limiting membrane on OCT. The correlations between vitreous haze and vitreous particles were also evaluated. Results Thirty-three eyes from 23 patients with active posterior uveitis were included. IFU had significantly more particles than NIGU and NINGU ( P =0.03 and P <0.001, respectively). The vitreous particle density was higher in IFU than in NIGU and NINGU ( P =0.03 and P =0.003, respectively). The mean largest particle size was greater in IFU and NIGU than in NINGU ( P =0.01 and P =0.03, respectively). The median vitreous haze of 2+ in IFU, 1+ in NIGU and NINGU showed no significant difference among three groups ( P =0.21). Conversely, the correlation of the largest particle size with vitreous haze was significant at ρ = 0.44 ( P =0.01). Conclusion SD-OCT may be useful for assessing ocular inflammation based on morphological characteristics of vitreous particles on the uveitis classification basis.

What was known・A high incidence of intraocular inflammation (IOI) after intravitreal brolucizumab (IVBr) administration has been reported, and occlusive vasculitis, which can be associated with vision loss, has been considered as a severe phenotype of IOI.・The risk factors of IVBr-associated IOI have not been fully elucidated. What this study adds・After IVBr administration as switching therapy for nAMD, 18 (20.6%) eyes developed IOI and 2 (2.3%) exhibited retinal artery occlusion. ・Macular atrophy and subretinal hyperreflective material on optical coherence tomography (OCT) increased the risk of developing IVBr-associated IOI.

Microhook trabeculotomy (μLOT), recently developed by Tanito belongs to minimally invasive glaucoma surgery and contributes to intraocular pressure (IOP) control in eyes with glaucoma resistant to medical therapy. In this study, we aimed to investigate the effectiveness and safety of μLOT for uveitic glaucoma. The medical records of consecutive 36 eyes from 30 patients who underwent μLOT and were followed up over post-operative 1 year were reviewed. The surgical success (IOP = 5–20 mmHg and ΔIOP ≥ 20% with additional anti-glaucoma drugs) was achieved in 67% of eyes at post-operative 12 months. The median IOP significantly decreased from 30.5 mmHg pre-operatively to 15 mmHg at 12 months post-operatively (p = 0.001), and the median glaucoma drug score changed from 5 pre-operatively to 2.5 at 12 months post-operatively (p = 0.301). Intraocular inflammation scores at post-operative 6 weeks did not show a significant worsening as compared to pre-operatively, and 8 (22%) eyes exhibited exacerbation of inflammation during the 12-month follow-up period. Post-operative complications were confirmed in 58% of eyes, but most of them were mild and transient or successfully managed. With its favorable benefit–risk profile, μLOT would be an option worth considering as the first glaucoma surgery for uveitic glaucoma.