Background: Implementation of evidence-based nursing guidelines for thyroidectomy patients can enhance their health outcomes by improving compliance and promoting healthy lifestyles. Aim of study: This study aimed to evaluate the effectiveness of an evidence based nursing guidelines on thyroidectomy patients' health outcomes at General Surgery departments.. Research design: A Quasi -experimental research design was conducted to achieve the aim of this study. Subjects: A purposive subject of 80 adult patients who were admitted within 9 months in the General Surgical departments at Benha University Hospital, scheduled for thyroidectomy surgeries and accepted to participate in this study. Setting: This study conducted in General Surgical departments and outpatient surgical clinic at Benha University Hospital. Tools of data collection: three tools were used in this study: I: Structured questionnaire assessment. II: Patients Practical observational checklist and III: Patients' health outcomes assessment. Results: There was statistically significance improvement in patient's knowledge, practice and health outcomes immediately, on 7 th days and one-month post implementing of evidence based nursing guidelines compared to pre implementing evidence based guidelines (p =<0.001) and a positive significant correlation between patients' knowledge and practice was found immediately, on 7 th days and onemonth post implementing of an evidence based nursing guidelines. Conclusion: Implementing of an evidence based nursing guidelines for thyroidectomy patients had improved of patients' health outcomes through high significantly increased level of their knowledge, practice and compliance to discharge instructions scores, and decreased overall postoperative complications rate. Recommendations: Developing and designing an in-service training program for nurses' staff members on applying the evidence-based nursing practice in the field of surgical nursing care including pre and postoperative management, especially for thyroidectomy patients.
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