A series of hydroxybenzenesulfonyl fluorides and derivatives thereof was synthesized and evaluated as fast plant desiccants. Their activity was compared with the plant response of some hydroxybenzenesulfonyl chlorides and other related benzenesulfonyl compounds, and with some structurally unrelated commercial products. Structure-activity relationship is discussed. 3-Chloro-4-hydroxybenzenesulfonyl fluoride, 3,5-dichloro-4-hydroxybenzenesulfonyl fluoride, and 3,6-dichloro-4-hydroxybenzenesulfonyl fluoride caused considerable desiccation in 1 to 5 days in field tests.
Ka of 0.01 and * of 0.10, Et and Me derivatives should have similar optimum partition coefficients.The data in this report substantiate this observation.This study demonstrates the usefulness of the extrathermodynamic approach in understanding structureactivity relationships. Thus, the antibacterial activities of leucomycins, as well as lincomycin and clindamycin analogs depend on their relative hydrophobic Popoff, el al.properties. Through use of dummy variables, steric effects could be examined in the lincomycin series. Finally, a comparison of the optimum value for one subseries with that of another subseries results in the indication of an electronic effect. In the case of the leucomycin series the electronic and steric effects could not be separated because of lack of variety in the derivatives tested.
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