Adjuvant chemotherapy for superficial transitional cell bladder carcinoma: long-term results of a European organization for research and treatment of cancer randomized trial comparing doxorubicin, ethoglucid and transurethral resection alone Kurth, K-H.; Tunn, U.; Ay, R.; Schroder, F.H.; Pavone-Macaluso, M.; Debruyne, F.; ten Kate, F.J.W.; de Pauw, M.; Sylvester, R.
Published in:The journal of urology
DOI:10.1016/S0022-5347(01)64484-7Link to publication Citation for published version (APA): Kurth, K-H., Tunn, U., Ay, R., Schroder, F. H., Pavone-Macaluso, M., Debruyne, F., ... Sylvester, R. (1997). Adjuvant chemotherapy for superficial transitional cell bladder carcinoma: long-term results of a European organization for research and treatment of cancer randomized trial comparing doxorubicin, ethoglucid and transurethral resection alone. The journal of urology, 158, 378-384. https://doi.org/10.1016/S0022-5347(01)64484-7
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ABSTRACTPurpose: We compared the efficacy of transurethral resection alone or transurethral resection followed by bladder instillations of doxorubicin or ethoglucid for 1 year in patients with superficial bladder carcinoma, and followed them long term for the incidence of progression to muscle invasion.Materials and Methods: A total of 443 patients with superficial transitional cell carcinoma of the bladder was randomized. After randomization of 206 patients the control arm was closed to patient entry based on the results of an interim analysis showing a significant difference in favor of those receiving adjuvant chemotherapy.Results: Final analysis of treatmeat results for recurrence included 432 patients at a median followup of 3.4 years for time to first recurrence, 5 years for analysis of time to invasion (Category T2 disease or worse) and 10.7 years for duration of survival. Time to first recurrence was significantly prolonged by both drugs compared to transurethral resection alone (doxorubicin versus transurethral resection alone p <0.001 and ethoglucid versus control p <0.001). Recurrence rate per year was 0.30 for both adjuvant treatment arms and 0.68 for the resection only group. Progression to muscle invasion was rare (15.1% of cases) and not apparently different in the 3 treatment arms. Of ...