Five cases of probably intrauterine herpesvirus infection are discussed. Four of them had clinical evidence of neonatal herpes, which was diseminated in two patients, localized to skin in one case and w ; th SNC compromised in other. Natal or post natal infections we^e not considered to be possible in these infants due to the presence of symptoms in the first 24 hours of life, which made ascending transcervicat or transplacental the most probable route for viral transmission. All cases were treatec with a ten days course of intravenous acyclovir during 10 days. There of them had satisfactory evolution and the other two died at 9 days and at 2 months of life. (Keywords: herpes simplex, infection, prenatal.) El herpes neonatal es una enfermedad graveLa transmision natal es la forma mas frecucnte cuya principal fuente de infeccion es la transmi-y ocurre en el paso por el canal genital materno sion de la madre al hijo, que puede producirse infectado 3 . La transmision prenatal es menos en el perfodo prenatal, natal o postnatal 1 ' 2 , frecuente, pero puede causar aborto, malformaclones, parto premature e infeccion congenita.
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