Pregnancy is a physiological condition start from fertilization to delivery. The mother and the fetus are exposed to serious complications during pregnancy. Variations in the antioxidant protection mechanism characterize this condition. The aim of this study was to estimate serum ceruloplasmin activity (Cp) and some biochemical parameters levels as markers of oxidative stress in serum of women with pregnancy complications compared to women with healthy pregnancies as control group and study the correlation between them. The study included (70) serum samples divided into (45) samples as patients with pregnancy complications which are sub-divided to the following groups: preeclampsia, anemia and Abortion and (25) samples of women with healthy control group. All of the studied groups showed non-significant difference in total protein level and ceruloplasmin activity except abortion group which had a significant decrease when compared to other groups. All studied groups showed non-significant differences in free amino, thiol and carbonyl levels, while abortion group showed significant decrease in carbonyl levels. In addition, all of the studied groups showed a non-significant increase in copper (Cu) levels, except for abortion group, that showed a significant decrease. Finally, all of the studied groups showed a non-significant increase in iron (Fe) levels, except the preeclampsia group, that showed a significant increase as compared to other groups.