Aim:The aim of this study was to determine the wettability of different hydrophilic and hydrophobic elastomeric impression materials and the gypsum castability. Materials and methods:The wettability was evaluated by determining the contact angles of different elastomeric impression materials. The contact angle was determined by placing a drop of aqueous solution of calcium sulfate dihydrate on the flat surface of impression material and specimens were measured using a profile projector.Gypsum castability was determined by counting the number of voids formed in the die stone cast made from the impressions of a aluminum die. The voids were counted using an diopter magnifying lens. Results:Polyether, different viscosities of polyvinyl siloxane, and condensation silicone impression materials exhibited low contact angle values and least number of voids in the die stone cast when compared with polysulfide impression material. Conclusion:There was significant correlation between the contact angle and voids formed in the die stone casts when fabricating die stone casts from various elastomeric impression material impressions.Clinical significance: Accurate reproduction of prepared tooth or edentulous arch is of clinical importance in the fabrication of a fixed or removable prosthesis. Inaccuracies in the replication processes will ultimately have an adverse effect on the fit and adaptation of final restoration. The interaction is determined in part by hydrophilic and hydrophobic nature of the elastomeric impression material. Inadequate wetting of an impression results in voids in the stone casts.