A series of novel scaffolds Thiadiazolyl Piperidine, Thiadiazolyl Piperazine, thiadiazolidine, Thiadiazolyl thiazole and Thiadiazolyl-imidazole-Thione were synthesized from cheap, available and biologically active stearic acid. 2-amino-5-heptadecyl 1,3,4-thiadiazole reacts with chloroacetyl chloride and produced 2-choloro-N-(5-heptadecyl-1,3,4-Thiadiazole-2-yl) acetamide. Which allowed to react with Piperidine, Piperazine, urea and/or Thiourea and Potassium thiocyanate, and the latest scaffolds have been synthesized, respectively, and the structures of these compounds were established by elemental analysis, MS, IR and 1 H-NMR spectral data. The antimicrobial activities of the synthesized compounds were evaluated in-vitro against strains of gram +ve, gram −ve bacteria and fungi. Nonionic surfactant were obtained by addition of different moles of propylene oxide (3,5,7 mole) to the synthesized compounds bearing an active hydrogen. Physico-chemical and surface properties as well as biodegradability of the synthesized non-ionic surfactants were evaluated.
T he low molecular weight mycotoxins that fungi create are secondary metabolic products. They hurt economies significantly and are present in about 25% of cultures globally (Magnoli et al., 2017). Mycotoxins (B1, B2, G1, and G2) that can contaminate cereals include aflatoxin, which is a byproduct of the metabolism of the fungus Aspergillus spp (Buszewska-Forajta 2020). Because it has hepatotoxic, carcinogenic, and teratogenic properties, aflatoxin B1 (AFB1), which is produced by the fungus Aspergillus flavus and Aspergillus parasiticus, is regarded as the most toxic of the four varieties (Anater et al., 2020).
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