A novel synthetic methodology to diblock copolypeptides was developed by ring‐opening polymerization (ROP) of N‐carboxyanhydrides (NCAs) from α‐ω‐functionalized initiators combined with the Huisgen 1,3 dipolar cycloaddition (click chemistry). Poly(γ‐benzyl‐L‐glutamate) (PBLGlu) and poly(trifluoroacetyl‐L‐Lysine) (PTFALys) containing either an azide or an alkyne functional group in α‐position were first synthesized by ROP of the corresponding NCA at room temperature in DMF as a solvent, using appropriate ω‐amino‐containing α‐alkyne and α‐azido difunctional initiators. The copper(I)‐catalyzed coupling reactions of α‐azido‐PBLGlu with the α‐alkyne‐PTFALys, on the one hand, and of the α‐alkyne‐PBLGlu with the α‐azido‐PTFALys, on the other hand were suitably accomplished in DMF. This afforded the targeted PBLGlu‐b‐PTFALys diblock copolypeptides possessing a triazole group in between the two blocks, as evidenced by SEC, IR, and NMR analysis. Block copolypeptides could be successfully purified by selective extraction with chloroform.magnified image
Design of materials with polymer-like properties at service temperature but able to flow like simple liquids when heated remains one of the important challenges of supramolecular chemistry. Combining these antagonistic properties is highly desirable to provide durability, processability, and recyclability of materials. Here, we explore a new strategy based on polycondensation reactions to design supramolecular polymer materials with stress at break above 10 MPa and melt viscosity lower than 1 Pa·s. We report the synthesis and rheological and mechanical properties (uniaxial tensile tests) of supramolecular polymers based on a multiblock polyamide architecture. The flexibility of polycondensation reactions made it possible to control the molecular size distribution, the strength of hydrogen bonds, and the crystallization of middle and end groups and to achieve targeted properties.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.