This review highlights strategies for the enantioselective total synthesis of cyclolignan natural products from 2000 to 2021. Each subsection focuses on the key strategic disconnections and the enantioselective steps controlling asymmetric induction.
Diastereoselective oxidative coupling
of ketones through a silyl
bis-enol ether intermediate by anodic and photocatalytic oxidation
is reported. These methods provide several 1,4-diketones in good yields
without the need for stoichiometric metal oxidants. The strategic
use of a silicon tether enables the coupling of both aromatic and
aliphatic ketones as well as the synthesis of quaternary centers.
Cyclic voltammetry is used to gain insight into the oxidation events
of the reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.