New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia. The code and resources are available at http://compbio.sph.harvard.edu/hidelab/pathprint
and Sue are core members of the Gateway Team of full-time faculty in the College of Engineering at Northeastern University in Boston, MA. While they concentrate on first-year engineering courses teaching across all engineering disciplines, they also teach specialty courses in the Department of Mechanical and Industrial Engineering at NU. Each of the NU team has published and presented papers on approaches and techniques in engineering education. Combined, Sue, Rich, and Beverly have earned several teaching awards and are proponents of active, engaging, and effective learning practices.
Since Weiser's vision in 1991 for ubiquitous (also called pervasive) computing there has been little tangible progress towards it. However, over time the communications industry has begun to erode many of the hardware barriers to this vision. Even so, the utopia of pervasive computing remains out of reach, primarily as a result of the continued fixation with devices and connectivity as a way to realise mobility. However, it could be argued that users ultimately require access to information or content irrespective of the devices and connectivity around them. Consequently, pervasive information is seen as the key to true user mobility. This paper will introduce a potential secure pervasive information architecture that fits Weiser's vision, and position it with respect to a sub-set of current contenders for future systems from both academia and the telecommunications industry, and highlight their strengths and weaknesses.
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