Aims To investigate the hypothesis that use of antibiotics is related to subsequent development of breast cancer and also to apply this theory to other cancer types. Materials and methods A nested case-control study was conducted, using data linkage between the RNZCGP Research Unit database and the New Zealand Hospital Separation Diagnosis database. Cancer related hospital admissions were identified between 1998 and 2002, and prior antibiotic exposure in these patients was then found. Results A total of 6678 patients were identified with a newly diagnosed cancer in this time period. A slightly increased odds ratio (OR) (95% CI) for breast cancer was seen with penicillin, 1.07 (1.02-1.13). Penicillin was also associated with an increased OR with lung and respiratory cancer, 1.13 (1.06-1.21), and skin neoplasms, 1.05 (1.02-1.08). Significant associations were seen between macrolides and leukaemia, 1.15 (1.01-1.30), lung and respiratory cancers, 1.23 (1.10-1.38) and non-Hodgkin's lymphoma, 1.26 (1.02-1.55). Tetracyclines were significantly associated with non-Hodgkin's lymphoma, 1.12 (1.01-1.24). Cephalosporins only showed a significant association with leukaemia, 1.35 (1.06-1.71), sulphonamides with colorectal cancers, 1.12 (1.01-1.24), and 'other' antibiotic classes with bladder and renal cancers, 1.34 (1.07-1.67). Conclusions It is most likely that antibiotic exposure represents a confounding factor rather than a causation for breast cancer and other cancer types.
AimTo identify the incidence and risk of suicide and self harm, among patients prescribed antidepressant drugs. MethodsA retrospective cohort study, with nested case control, of patients identified from a nonrandom sample of general practices in New Zealand from 1996 to 2001. A total of 57 361 patients who received a prescription for a single antidepressant were identified from the RNZCGP Research Unit Database. Suicides within 120 days of a prescription were identified from the New Zealand National Mortality Database and self-harm events within 120 days of a prescription were identified from the New Zealand Hospital discharge database.Results 26 suicides and 330 episodes of self-harm were identified within 120 days of an antidepressant prescription. On univariate analysis the association, expressed as OR (95% CI), between selective serotonin reuptake inhibitors (SSRIs) and self harm and suicide were 2.26 (1.27-4.76) and 1.92 (0.77-4.83), respectively. When corrected for the confounding effects of age, gender and depression/suicidal ideation there was an association between SSRIs and self harm, OR 1.66 (95% CI 1.23-2.23), but not for suicide, 1.28 (0.38-4.35). Paroxetine was a significant risk factor for suicide on univariate analysis, 4.23 (1.19-14.95), but not when corrected for age, gender and depression/suicidal ideation, 2.76 (0.30-24.87). ConclusionsAge, gender and pre-existing depression/suicidal ideation are impor tant confounders in observational studies of the association between antidepressants and suicide or self harm.
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