Background. Polycystic ovary syndrome (PCOS) is a typical female disorder that influences different aspects of women’s health. There is a direct association between inflammation and PCOS status. Some evidence supports the beneficial effects of exercise on inflammation status in PCOS women, while others cannot find a significant association. This study aimed to clarify the effect of exercise on inflammatory markers in women with PCOS. Method. Electronic searches in international databases were performed to identify eligible publications up to August 2021, which compared the effects of exercise on inflammatory markers in the intervention group compared to the control group in PCOS women. A weighted mean difference (WMD) using a random-effect model was applied for reporting results. Results. A total of 2525 records were found via database searching, of which 10 were eligible to be included in the analysis. The results of the meta-analysis revealed that exercise could significantly lower the serum level of CRP (WMD: −0.43 mg/L; 95% CI: −0.66 to −0.21; P ≤ 0.01 ; I2: 84.9%; P < ≤ 0.01 ), while it was not considerable for adiponectin (WMD: −0.33 μg/mL; 95% CI: −0.97 to 0.31; P = 0.30 ; I2: 0%; P = 0.97 ). In addition, subgroup analyses indicated a significant effect of exercise on CRP in individuals ≥30 years, sample size ≥15 individuals, and aerobic training. Conclusion. Exercise training can reduce CRP levels in women with CRP, particularly in women older than 30 years of age, and in studies with more than 15 participants. The effect of exercise on adiponectin was not noticeable.

Background: Many patients, chiefly teenagers, seek effective treatment for acne vulgaris. Besides topical treatments, antibiotics, and anti-androgens, herbal treatments have been used against it. Objectives: This study aims to evaluate the effects of an herbal combination based on Prunus domestica L., Tamarindus indica L., Terminalia chebula L., Ziziphus jujube L., and Cassia fistula L. on acne vulgaris. Methods: This randomized, triple-blind, placebo-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate acne vulgaris. Patients were randomized, 55 in each group, to receive either herbal syrup or placebo (10 cc every 8 hours) for 12 weeks and were followed for 4 weeks. The severity of acne and participants’ psychological status was assessed by acne severity index (ASI) and Cardiff acne disability index (CADI), respectively. Results: No significant changes were observed up to the sixth week of treatment in both groups (P ≥ 0.05). From 6 weeks to 12 weeks, the outcomes indicated a significant reduction in the mean number of comedones (P < 0.030), papules (P < 0.045), pustules (P < 0.026), nodules (P < 0.044), and ASI (P < 0.001) in the herbal syrup group compared to the placebo group. Nevertheless, this did not continue after 4 weeks of follow-up (16th week). Conclusions: The herbal syrup could be an alternative treatment in patients with mild to moderate acne vulgaris. Indeed, more clinical trials are needed to confirm its efficacy and safety.