Spontaneous adrenal hemorrhage (SAH) is a serious medical condition associated with variable clinical presentation depending on the extent of the hemorrhage. Pregnancy-induced adrenal hemorrhage is poorly understood. A low cortisol level in the peripartum period with radiological findings is sufficient to establish the diagnosis. Prompt hormone replacement and supportive care to ensure good clinical outcomes is crucial. Due to the potentially life-threatening complications, physicians should have a high suspicion for adrenal hemorrhage when they evaluate patients with hypotension, fatigue, and abdominal pain during the peripartum period.
Chronic myeloid leukemia (CML), a hematologic malignancy characterized by unregulated growth of myelogenous leukocytes, typically presents with symptoms of fatigue, anorexia, and splenomegaly. Laboratory studies often reveal a significant leukocytosis with neutrophilia. A moderate thrombocytosis may be present, but is not usually problematic. The following case discusses a patient who presented with syncope, a convulsive episode, and non ST-segment myocardial infarction secondary to symptomatic thrombocytosis of 2.5 million cells/microL. She was treated with plateletpheresis and subsequently experienced resolution of symptoms. Ultimately, a diagnosis of CML with an atypical presentation of the disease was identified in this patient.
Posterior reversible encephalopathy syndrome (PRES) is a neurological condition characterized by headaches, visual disturbances, and seizures. A magnetic resonance imaging (MRI) scan of an affected brain typically shows symmetrical white matter edema in the posterior cerebral hemispheres. The onset of PRES can constitute a medical emergency, especially when accompanied by status epilepticus. If promptly recognized and treated, the clinical syndrome and associated radiological findings are usually resolved in a matter of weeks or months. Carfilzomib is a proteasome inhibitor that is newly approved for relapsing myeloma in a patient who has received one or more lines of therapy. In this paper, we report on a 52-year-old female on carfilzomib for multiple myeloma who developed PRES following her second dose of treatment. She was admitted for chronic obstructive pulmonary disease (COPD) exacerbation, and while she was in the hospital, she developed a severe headache, blindness, and status epilepticus. A brain MRI showed signs consistent with PRES. After carfilzomib was discontinued, her symptoms resolved within three days. Unfortunately, the patient passed away shortly after being discharged, so there was no opportunity to perform a repeat MRI.
Introduction Left ventricular dysfunction was observed after repair of coarctation of the aorta (COA) before development of left ventricular concentric hypertrophy. Aim The aim of this study was to assess the the LV functions after COA repair. Methods Thirty pediatric patients with COA repair underwent echocardiographic examinations using Conventional echocardiography, tissue doppler image (TDI) and 2D-STE. Results The LV systolic functions assessed by TDI and 2-D-STE showed a significant reduction of (S׳׳LW LV, IVA at LW LV, IVA at the septum, longtudinal strain (LS) basal and global radial (GRS) in cases compared to control group . There is significant increase in GCS in cases compared to control group, the conventional Doppler derived MPI of LV in post coarctation repair cases was significantly prolonged compared to control. Analysis of mitral annulus velocities including E", A", E"/A" ratio and E/E′ ratio revealed worsening of the left ventricular diastolic mechanics in the post COA repair cases compared to healthy controls. The E" wave velocity (at the left ventricular lateral wall) was significantly lower in post COA repair in cases compared with controls , E"/A" ratio was significantly lower in post COA repair cases compared with controls . The E/E′ ratio was significantly higher in the post COA repair cases compared to the control group . Conclusions LV systolic and diastolic dysfunction was fount in patient after COA repair. LV systolic function by 2-D-STE Cases Control P value Mean SD mean SD GLS -21.51 2.79 -22.63 2.99 .094 LS basal -19.94 2.83 -22.63 2.99 <0.01 (S) LS Mid -21.08 2.75 -21.87 2.78 .273 LS apical -23.52 4.22 -21.74 4.23 .109 GRS 22.58 5.24 49.01 10.08 <0.01 (S) RS basal 20.92 8.29 43.56 18.95 <0.01 (S) RS mid 25.03 7.59 56.80 14.27 .223 RS apical 21.78 8.34 46.66 15.11 <0.01 (S) GCS -20.09 2.66 -16.73 2.78 <0.01 (S) CS basal -21.49 2.70 -16.98 4.69 <0.01 (S) CS mid -21.27 4.09 -15.83 3.67 <0.01 (S) CS apical -17.51 4.63 -17.39 4.57 .920
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