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Many frontline healthcare workers throughout the world have been exposed to COVID-19 infection in the workplace and the community. We describe the nature of infection and the durability of antibodies among various types of healthcare workers at an acute care community hospital in northern New Jersey adjacent to New York City, part of the epicenter of the first wave of the US epidemic. Exposure was concentrated among frontline workers and in clusters among support staff. The antibody response correlated with symptoms and job type.