In recent decades, metal oxide nanoparticles have acquired relevance in biology and medicine due to their unique physicochemical properties. Because of its cheap cost, biodegradability and low toxicity, zinc oxide nanoparticles (ZnO-NPs) have attracted a lot of interest from researchers for therapeutic and diagnostic applications. Zinc oxide (ZnO) has been studied for various biological applications due to its unique semiconducting, optical and piezoelectric characteristics. The growing interest in nano zinc oxide has led to the discovery and development of nanoparticle production technologies. ZnO nanocomposites with varied morphologies have recently been prepared using a physical and chemical method. ZnO NPs have also been employed to deliver different bioactive and chemotherapeutic anticancer medicines to tumour cells in a targeted and sustained manner. This review discusses on the properties, synthesis, drug delivery method for cancer treatment and many other biological uses of ZnO NPs.
The man-made xenoestrogen bisphenol S has been well-established and associated with developing neoplasm, dementia, neurotoxicity, anxiety, and other adverse effects in people and other organisms. The mechanisms of BPS-induced toxicity have been studied; however, it is unclear if there is any prospect for improvement by natural means. After being exposed to BPS through water, zebrafish (Danio rerio) were employed in this investigation to determine whether quercetin co-supplementation could lessen the compound's destructive potential. Laboratory tests were done to see if quercetin's antioxidant properties may shield the zebrafish brain from oxidative stress and altered behavioral responses brought on by BPS. The available evidence shows that quercetin is beneficial in reducing the abnormal behavioral response brought on by BPS. Quercetin (QU) may have therapeutic potential for reducing oxidative stress caused by BPS, according to biochemical research conducted in the zebrafish brain. In addition, quercetin guards the zebrafish brain against toxicity brought on by BPS. These preliminary findings imply that quercetin, which reduces the generation of reactive oxygen species, would be an effective treatment for BPS-induced toxicity in zebrafish.
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