dinucleotide phosphate, reduced form; ROE, rotating Overhauser effect; V max , maximal velocity; K M , substrate concentration at half-maximal velocity; CL int,app , apparent intrinsic clearance; CL int,app,scaled , scaled apparent intrinsic clearance; f u,mic , fraction unbound in liver microsomes; f CL , fractional clearance; f m , fraction metabolized; f a , fraction of the po dose absorbed from the gastrointestinal lumen; CL renal , renal clearance; Vd ss , steady state distribution volume; C max , maximal plasma concentration; T max , time to reach C max ; AUC, area under the plasma concentration-time curve; t 1/2 , half-life; P app , apparent absorptive permeability; MDCKII-LE, low efflux Madin-Darby canine kidney cells; BCRP, breast cancer resistant protein; MDR1, multidrug resistant gene 1; f u,p , plasma unbound fraction; BPR, blood to plasma ratio; CL hep , in