Background: Pamburus missionis is geographically originated from southern India and it has been used for ailments. Objectives: This current research was performed to analyze in silico evaluation of phytoconstituents present in Pamburus missionis for antioxidant activity. Materials and Methods: In silico activity of the isolated constituents for antioxidant activity was carried out by Autodock 4.0 and absorption, distribution, metabolism, excretion/toxicity assessed by online tools. Results: The results revealed that the phytocompounds, benzoic acid 2,3-dimethyl showed the good docking score of -5.8 kcal/mol, which was a mere docking score of standard curcumin, i.e., -6.6 kcal/mol hence proving that a good binding compatibility among the ligand and the receptor site NADPH oxidase. The Absorption, distribution, metabolism, excretion/toxicity evaluation of phytoconstituents assures that they had obeyed Lipinski's guideline of five suggesting their safety consumption. Conclusion: To conclude, Pamburus missionis can be a good resource of antioxidant activity and simulation studies is needed to ensure the antioxidant activity of benzoic acid 2,3-dimethyl.
Objective: The current study deals with detailed pharmacognostical study and preliminary phytochemical screening of leaf of Myxopyrum smilacifolium Blume. Myxopyrum smilacifolium Blume is a twining shrub belongs to the family Oleaceae. It is used traditionally in the treatment of cough, rheumatism, cephalalgia, notalagia and otopathy. Scrutinization of literature revealed that there is a lack of pharmacognostical and Phyto chemical investigations of Myxopyrum smilacifolium Blume. Methods: The macroscopical and microscopical features were evaluated. The leaves of Myxopyrum smilacifolium Blume was subjected for successive solvent extraction and further preliminary phytochemical screening was carried out and also the behaviour of powder with different reagents were evaluated by fluorescence analysis. Results: The detailed study of pharmacognostical evaluation showed the presence of thick walled epidermal cells covered with thick cuticle, xylem and phloem elements, Glandular trichome and slightly concave collateral vascular bundles. Preliminary Phytochemical examination revealed the presence of various phytoconstituents viz., alkaloids, glycosides, tannins, saponins, terpenoids, carbohydrates and fixed oils. The fluorescence analysis mani fested the behavioral variation of the powdered drug. Conclusion: The findings of the present study will be a referential information for identification and also useful for standardization of the plant material.
Pamburus missionis Swingle[1] is a small thorny shurb commonly called as kattunaranthi in tamil belonging to the family Rutaceae. The leaf of this plant is used traditionally for the treatment of fistula, joint swellings, rheumatism, fractures and piles. The anatomical and chemical investigations on Pamburus genus are very limited. Pamburus missionis Swingle is distributed in southern India. Earlier investigation was made on root and stem bark of Pamburus missionis S. and reported that it contains imperatorin, coumarins, diterpenes, flavones and xanthotoxis, isopimpinellin, scopoletin and luvangetin [2, 3].
Background:Worm infections in developing countries were reported high. Phytoconstituents have been a vital role for the treatment of many ailments. The current study was aimed assess for anthelmintic activity of different root extracts of Dechaschistia crotonifolia Wight & Arn. belongs to the family Ebanaceae against Pheretima posthuma. Further Insilico study was carried out for phytocompounds present in Dechaschistia. Results: The chloroform, ethylacetate and ethanol extract of Dechaschistia crotonifolia Wight & Arn. were considered for the study of anthelmintic property on earthworms at concentrations 20 mg/ml, 40 mg/ml and 60 mg/ml. During this study, the parameters paralysis time (Pt) and Death Time (Dt) of adult Indian earthworms was observed. As a standard and control Albendazole 10 mg/ml and 2% Tween 80 in distilled water were taken respectively. The study resulted that ethanolic extract was significant when compared with the Albendazole 10 mg/ml. Docking studies revealed the all phytocompounds in Dechaschistia shown binding affinity, however comparatively scopoletin and stigmasterol had shown a good binding affinitiy about -7.7 Kcal/mol and -7.6 Kcal/mol compared to standard drug Albendazole which was shown about -8.7 Kcal/mol. Conclusion: The study revealed that the ethanol extract of Dechaschistia crotonifolia Wight & Arn. at a concentration of 60mg/ml exhibited a stronger anthelmintic property compared to Albendazole 10mg/ml. A dose dependent anthelmintic activity is exerted by all the extracts in an ascending manner Chloroform<Ethyl acetate<Ethanol. These observations were made evidenced by docking studies of phytocompounds in Dechaschistia as the phytocompounds were shown excellent docking score when compared with standard Albendazole.
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