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From the aereal part of S a 1 v i a b a 11 o t a e f 1 o r a , BENTH (Lanziaceae) three new diterpene quinones were isolated, all with an abietane skeleton. One of them, romulogarzone is an o r t h oquinone, the other two, conacytone and icetzxone are pa r aquinones, their structures were elucidated on chemical and physical data.

A 29-gauge needle allows easy aspiration of the first MTP joint with only modest discomfort for the patients, and generally yields a SF sample of sufficient volume for crystal detection and identification.

In the framework of our search for leishmanicidal and antimalarial compounds from Colombian plants, and in continuation of our work on Aspidosperma species (1), we report herein the chemical study of Aspidosperma megalocarpon Mull. Arg. (Apocynaceae). Plants of this genus are used in Colombia against fever and rheumatism (2) and a polar extract of the trunk bark of A. megalocarpon has showed an in vitro antimalarial activity against several Plasmodium species. Our work concerns the isolation of three alkaloids: fendlerine (1), aspidoalbine (2) and aspidolimidine (3) from the trunk bark, which has never been reported thus far. A sample of A. megalocarpon was collected in March 1996 in Bajo Calima; a voucher specimen (BW 031) was deposited in the 1-lerbarium of the Universidad del Valle (Cali). 15 (÷) fendlerine (1): H, R2 CH2(23)-CH3(24) ' (+) aspidoalbine (2): IS R1 = OCH3, R2 CH2(23)-CH3(24) (+) aspidolimidine (3): R1 H, R2 = CH3(23)Dry ground bark (300 g) was moistened with 10% NH4OH and extracted with CH2CI2. The CH2CI2 extract was purified by a classical acid-base method (1) to give 3.6 g of an alkaloidal mixture (AM) (yield: 1.2 %). AM was fractioned by CC on silica gel (3 x 40 cm) using CH2C12-MeOH (95:5) as the eluent, 10 ml/min. Two main fractions: 1 (0.17 g) (between 200 and 450m1) and II (0.23g) (450-2300ml) were purified by preparative TLC (silica gel; CH2C12-MeOH 99: 1 with NH4OH vapors) to give in the following order of increasing polarity: 1 (in I, 5mg, 0.14% of AM), 2 (in II, 6mg, 0.16%), and 3 (in II, 8mg, 0.22 %).

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