The phenanthridine family is widely found in medicinal chemistry and material science because of the biological activity and the presence in a variety of significant natural products and synthetic dye-stuffs. The phenanthridine has many clinical application like anticancer agent, antibacterial, antiprotozoal, pharmaceutically, and optoelectronic properties. Many methods have been reported for the synthesis of phenanthridine and phenanthridine alkaloids such as Pd catalyzed C-C bond forming. Reaction involving C-H activation , Radical, Microwave-assisted , transition metal catalyzed, one- pot cascade, benzyne mediated, photochemical, hypervalent iodine promoted ,etc. Here we summarized the literature data from 2014 to present concerning a novel or improved synthetic approaches.
Isatins are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds. In this, a convenient method has been developed for the conversion of Indoles into Isatins and some heterocyclic derivative were synthesised such as 5-nitro-1H-indole-2,3-dione, 2-methylquinoline-4-carboxylic acid which may be used as raw material for drug synthesis. The general process utilizes the effective method for synthesis of Isatin from Indole is bromination and oxidation with an N-bromosuccinimide-dimethyl sulfoxide reagent. The nitration of Isatin at C-5 takes place by using KNO 3 , conc. H 2 SO 4 , 2-methylquinoline-4-caboxylic acid are usually obtained from pfitzinger reaction.
The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is study and synthesis of dihydropyrimidinones efficiently and in high yields under mild, solvent free and eco-friendly conditions by using "Grindstone Chemistry Technique" catalyzed by CuCl 2 ·2H 2 O and Conc. HCl. The obtained products have been identified by comparison with spectral data & their melting points. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH 4 Cl as a catalyst. 3,4-dihydropyrimidin-2-(1H)-ones was synthesized and characterized using IR. The melting points was obtained 203 °C.
The functionalization of organic molecules with the Schiff bases having benzothiazole moiety has grown
rapidly due to its multiple therapeutic and pharmacological properties. They have driven enormous
studies on their stereochemistry, bioactivity and synthetic attempts. The benzothiazole moiety is
infinitesimal but broadly used for industrial purposes and also exhibits a broad range of biological activities.
Study carried out on Schiff bases having benzothiazole had well-known promising activities like
antimicrobial, antimalarial, antifungal, antitubercular, antiviral, antitumor, analgesic, anti-inflammatory
and many more. This review brings forward a systematic and comprehensive survey of the reactivity
and biological properties associated with the Schiff bases-benzothiazole derivatives and their analogs.
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