Tizanidine and aceclofenac individually have shown efficacy in the treatment of low back pain. The efficacy and tolerability of the combination have not yet been established. The objective of the study was to evaluate the efficacy and safety of aceclofenac-tizanidine fixed dose combination against aceclofenac alone in patients with acute low back pain. This double-blind, doubledummy, randomized, comparative, multicentric, parallel group study enrolled 197 patients of either sex in the age range of 18-70 years with acute low back pain. The patients were randomized to receive either aceclofenac (100 mg)-tizanidine (2 mg) b.i.d or aceclofenac (100 mg) alone b.i.d for 7 days. The primary efficacy outcomes were pain intensity (on movement, at rest and at night; on VAS scale) and pain relief (on a 5-point verbal rating scale). The secondary efficacy outcomes measures included functional impairment (modified Schober's test and lateral body bending test) and patient's and investigator's global efficacy assessment. aceclofenac-tizanidine was significantly superior to aceclofenac for pain intensity (on movement, at rest and at night; P \ 0.05) and pain relief (P = 0.00) on days 3 and 7. There was significant increase in spinal flexion in both the groups from baseline on days 3 and 7 with significant difference in favour of the combination group (P \ 0.05). There were significantly more number of patients with excellent to good response for the aceclofenac-tizanidine treatment as compared to aceclofenac alone (P = 0.00). Both the treatments were well tolerated. In this study, aceclofenac-tizanidine combination was more effective than aceclofenac alone and had a favourable safety profile in the treatment of acute low back pain.
For the treatment of painful OA flare-ups, the etodolac-paracetamol combination can offer improved clinical outcomes by targeting multiple pain pathways. The results of the current study show that etodolac-paracetamol is more effective in the treatment of OA flare-up than etodolac alone.
This article examines the compositions of bone tissue grafting and presents tissue culture and engineering formally as an approach for orthopaedic surgery. We assessed articles on bone grafts, analyzed their properties, advantages, and restrictions, and delivered explanations on technologies, including bone-tissue engineering (BTE). Osteo graft materials range from real human bone autografts (self-grafts) to substitute materials that can be used as grafts. These can be used single-handedly or conjointly to improve bone healing and regeneration. Tissue engineering is a relatively newer and evolving alternative for reducing the challenges of bone grafts and improving the rehabilitation of bone fractures and defects. Shortly, the combination of scaffolds, healing factors, gene therapy, and, more recently, 3D printing of tissue-engineered constructs may yield new perceptions. Natural bone tissue has a nanocomposite structure that offers the right biological and physical characteristics. It is essential that the biomaterial resemble real bone tissue in order to regenerate bone tissue. Because they can offer the correct matrix environment, combine desirable biological features, and allow regulated, sequential distribution of numerous growth factors for the different phases of bone tissue regeneration, nanocomposites are the ideal alternative for bone tissue regeneration. This is because no single type of material can replicate the composition, structure, and characteristics of native bone. A relatively new class of materials called nanocomposite biomaterials combines a biopolymeric and biodegradable matrix structure with nanoscale fillers that are bioactive and easily resorbable. There are also some things to think about when using nanoparticles and nanocomposites as scaffolds in clinical settings for bone tissue engineering.
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